Hoshino T, Tazoe M, Nomura S, Fujiwara A
J Antibiot (Tokyo). 1982 Oct;35(10):1271-9. doi: 10.7164/antibiotics.35.1271.
Following the discovery of new anthracycline antibiotics, auramycins A and B and sulfurmycins A and B, we found 10 minor analogues of auramycins and sulfurmycins, C, D, E, F and G, from the culture broth of a mutant strain of Streptomyces galilaeus OBB-111 and prepared 2 analogues as the chemical derivatives from auramycin G and sulfurmycin G. All analogues have a sugar moiety at C-7 position of the aglycones. These analogues exhibit activities against Gram-positive bacteria and P388 leukemia.
在发现新的蒽环类抗生素金霉素A和B以及硫霉素A和B之后，我们从加利利链霉菌OBB - 111突变株的培养液中发现了金霉素和硫霉素的10种次要类似物C、D、E、F和G，并从金霉素G和硫霉素G制备了2种类似物作为化学衍生物。所有类似物在苷元的C - 7位都有一个糖部分。这些类似物对革兰氏阳性菌和P388白血病具有活性。
