用于振动圆二色性光谱学的仪器：方法比较和新进展。

Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments.

机构信息

Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607-7061, USA.

出版信息

Molecules. 2018 Sep 19;23(9):2404. doi: 10.3390/molecules23092404.

DOI:10.3390/molecules23092404

PMID:30235902

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6225159/

Abstract

Vibrational circular dichroism (VCD) is a widely used standard method for determination of absolute stereochemistry, and somewhat less so for biomolecule characterization and following dynamic processes. Over the last few decades, different VCD instrument designs have developed for various purposes, and reliable commercial instrumentation is now available. This review will briefly survey historical and currently used instrument designs and describe some aspects of more recently reported developments. An important factor in applying VCD to conformational studies is theoretical modeling of spectra for various structures, techniques for which are briefly surveyed.

摘要

振动圆二色性（VCD）是一种广泛用于确定绝对立体化学的标准方法，在生物分子特征和动态过程研究中也有一定的应用。在过去的几十年中，不同的 VCD 仪器设计已经发展出了各种用途，并且现在已经有可靠的商业仪器可供使用。这篇综述将简要地介绍历史上和目前使用的仪器设计，并描述一些最近报道的发展的方面。将 VCD 应用于构象研究的一个重要因素是各种结构的光谱的理论建模，简要地介绍了这些技术。