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手性在大麻素研究中的作用。

Chirality in Cannabinoid Research.

机构信息

PerkinElmer Health Sciences, Inc., Waltham, Massachusetts, USA.

出版信息

Cannabis Cannabinoid Res. 2021 Feb 12;6(1):1-4. doi: 10.1089/can.2020.0027. eCollection 2021.

DOI:10.1089/can.2020.0027
PMID:33614946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7891190/
Abstract

Mankind has long utilized for diverse purposes. However, it has only been since the late 19th century that its individual cannabinoids began to be isolated, analyzed, and synthesized. By the mid-20th century it was discovered that many cannabinoids were asymmetric, with chirality often controlling their pharmacology. Increasingly accurate measurement and understanding of cannabinoid chirality will facilitate their synthesis and accelerate their medicinal applications.

摘要

人类长期以来一直将大麻用于各种用途。然而,直到 19 世纪后期,大麻的各种单一成分才开始被分离、分析和合成。到了 20 世纪中叶,人们发现许多大麻素都是不对称的,手性往往控制着它们的药理学。对大麻素手性的日益精确的测量和理解将有助于它们的合成,并加速它们的药用应用。

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Chirality in Cannabinoid Research.手性在大麻素研究中的作用。
Cannabis Cannabinoid Res. 2021 Feb 12;6(1):1-4. doi: 10.1089/can.2020.0027. eCollection 2021.
2
Looking back at Cannabis research.回顾大麻研究。
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Cannabinoids, Phenolics, Terpenes and Alkaloids of .. 的大麻素、酚类、萜烯和生物碱
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Cannabinoid pharmacology: the first 66 years.大麻素药理学:头66年
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The Cannabis Spread throughout the Continents and its Therapeutic Use in History.大麻在各大洲的传播及其在历史上的治疗用途。
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Potency testing of cannabinoids by liquid and supercritical fluid chromatography: Where we are, what we need.大麻素的液体和超临界流体色谱法效价测定:我们所处的位置,我们的需求。
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本文引用的文献

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A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ-tetrahydrocannabinol: Δ-Tetrahydrocannabiphorol.一种从大麻属植物中分离得到的新型植物大麻素,其体内大麻样活性高于 Δ-四氢大麻酚:Δ-四氢大麻酚醇。
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Microcrystal Electron Diffraction (MicroED) for Small-Molecule Structure Determination.用于小分子结构测定的微晶电子衍射(MicroED)
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Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments.用于振动圆二色性光谱学的仪器:方法比较和新进展。
Molecules. 2018 Sep 19;23(9):2404. doi: 10.3390/molecules23092404.
4
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography.透过镜子看大麻:通过对映体选择性超高效超临界流体色谱法对植物大麻素进行化学和对映体选择性分离
Chem Commun (Camb). 2017 Nov 14;53(91):12262-12265. doi: 10.1039/c7cc06999e.
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Characterization of the synthetic cannabinoid MDMB-CHMCZCA.合成大麻素MDMB-CHMCZCA的特性分析。
Beilstein J Org Chem. 2016 Dec 21;12:2808-2815. doi: 10.3762/bjoc.12.279. eCollection 2016.
6
Phytochemistry of Cannabis sativa L.大麻的植物化学
Prog Chem Org Nat Prod. 2017;103:1-36. doi: 10.1007/978-3-319-45541-9_1.
7
Phytocannabinoids: a unified critical inventory.植物大麻素:统一的关键清单。
Nat Prod Rep. 2016 Nov 23;33(12):1357-1392. doi: 10.1039/c6np00074f.
8
Preparative enantiomeric separation of new selective CB2 receptor agonists by liquid chromatography on polysaccharide-based chiral stationary phases: determination of enantiomeric purity and assignment of absolute stereochemistry by X-ray structure analysis.采用多糖手性固定相高效液相色谱法对新型选择性 CB2 受体激动剂进行制备对映体拆分:通过 X 射线结构分析测定对映体纯度和绝对立体化学构型。
Chirality. 2011 May;23(5):389-96. doi: 10.1002/chir.20939. Epub 2011 Mar 23.
9
History of cannabis as a medicine: a review.大麻作为药物的历史:综述
Braz J Psychiatry. 2006 Jun;28(2):153-7. doi: 10.1590/s1516-44462006000200015. Epub 2006 Jun 26.
10
Chemical constituents of marijuana: the complex mixture of natural cannabinoids.大麻的化学成分:天然大麻素的复杂混合物。
Life Sci. 2005 Dec 22;78(5):539-48. doi: 10.1016/j.lfs.2005.09.011. Epub 2005 Sep 30.