College of Food Science, Southwest University, Chongqing, 400715, People's Republic of China.
College of Food Science, Southwest University, Chongqing, 400715, People's Republic of China; Chongqing Engineering Research Center for Special Foods, Chongqing, 400715, People's Republic of China.
Food Chem Toxicol. 2018 Nov;121:404-412. doi: 10.1016/j.fct.2018.09.026. Epub 2018 Sep 17.
Coreopsis tinctoria flowers, a well-known medicinal and edible plant, have been reported to possess antioxidant and anti-inflammatory activities. However, its protective effects and underlying mechanisms on liver injury remain unclear. The aim of this study was to investigate the underlying mechanisms by which Coreopsis tinctoria flowers phenolic extract (CTP) alleviated D-galactosamine and lipopolysaccharide (D-GalN/LPS) induced acute liver injury in mice. Our results showed that pretreatment with CTP improved liver histology while decreased levels of serum aminotransferase and malondialdehyde. CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARα), and peroxisome proliferator-activated receptor gamma (PPARγ). In conclusion, results suggested that CTP protected against D-GalN/LPS -induced acute liver injury by up-regulation of Nrf2, PPARα, and PPARγ.
金鸡菊花，一种著名的药食两用植物，已被报道具有抗氧化和抗炎活性。然而，其对肝损伤的保护作用及其机制尚不清楚。本研究旨在探讨金鸡菊花酚提取物（CTP）缓解 D-半乳糖胺和脂多糖（D-GalN/LPS）诱导的急性肝损伤的潜在机制。结果表明，CTP 预处理可改善肝组织学，同时降低血清转氨酶和丙二醛水平。CTP 通过上调核因子红细胞 2 相关因子 2（Nrf2）、过氧化物酶体增殖物激活受体α（PPARα）和过氧化物酶体增殖物激活受体γ（PPARγ），增加 D-GalN/LPS 诱导的急性肝损伤小鼠的谷胱甘肽水平。总之，结果表明 CTP 通过上调 Nrf2、PPARα 和 PPARγ 来防止 D-GalN/LPS 诱导的急性肝损伤。
