Nichol S T, Holland J J
J Virol. 1987 Jan;61(1):200-5. doi: 10.1128/JVI.61.1.200-205.1987.
Sequence analysis of the RNA genome termini of various vesiculovirus standard and defective interfering (DI) particles demonstrated that some virus regulatory sequences and domains of virus N protein are highly conserved while others show considerable divergence. Clearly, distinct RNA signal sequences and protein-coding regions of these virus genomes have quite different evolutionary pressures or constraints. Terminal regions of DI-particle RNA genomes of these viruses were found to possess self-complementary stems at the RNA termini, demonstrating the conservation of this DI-particle structural feature throughout the vesiculovirus group. A high degree of conservation of the 3'-terminal sequences of recent and historic isolates of vesicular stomatitis virus New Jersey was also demonstrated.
对各种水疱性口炎病毒标准毒株和缺陷干扰（DI）颗粒的RNA基因组末端进行序列分析表明，一些病毒调控序列和病毒N蛋白结构域高度保守，而另一些则表现出相当大的差异。显然，这些病毒基因组不同的RNA信号序列和蛋白质编码区域具有截然不同的进化压力或限制。发现这些病毒DI颗粒RNA基因组的末端区域在RNA末端具有自我互补茎，这表明这种DI颗粒结构特征在水疱性口炎病毒组中是保守的。还证明了水疱性口炎病毒新泽西州近期和历史分离株3'末端序列的高度保守性。
