水痘-带状疱疹病毒补充1型单纯疱疹病毒温度敏感突变体。
Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants.
作者信息
Felser J M, Straus S E, Ostrove J M
出版信息
J Virol. 1987 Jan;61(1):225-8. doi: 10.1128/JVI.61.1.225-228.1987.
Abstract
Varicella-zoster virus (VZV) can complement temperature-sensitive mutants of herpes simplex virus. Of seven mutants tested, two, carrying mutations in the immediate-early ICP4 and ICP27 proteins, were complemented. This complementation was not seen in coinfections with adenovirus type 5 or cytomegalovirus. Following transfection into CV-1 cells, a DNA fragment containing the VZV short repeat sequence complemented the ICP4 mutant. These data demonstrate a functional relationship between VZV and herpes simplex virus and have allowed localization of a putative VZV immediate-early gene.
摘要
水痘带状疱疹病毒（VZV）可以互补单纯疱疹病毒的温度敏感突变体。在测试的七个突变体中，两个在立即早期ICP4和ICP27蛋白中携带突变的突变体得到了互补。在与5型腺病毒或巨细胞病毒的共感染中未观察到这种互补作用。将含有VZV短重复序列的DNA片段转染到CV-1细胞后，其互补了ICP4突变体。这些数据证明了VZV与单纯疱疹病毒之间的功能关系，并确定了一个假定的VZV立即早期基因的定位。
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