Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Science. 2018 Sep 21;361(6408). doi: 10.1126/science.aat2456.
Antagonistic interactions are abundant in microbial communities and contribute not only to the composition and relative proportions of their members but also to the longer-term stability of a community. This Review will largely focus on bacterial antagonism mediated by ribosomally synthesized peptides and proteins produced by members of host-associated microbial communities. We discuss recent findings on their diversity, functions, and ecological impacts. These systems play key roles in ecosystem defense, pathogen invasion, spatial segregation, and diversity but also confer indirect gains to the aggressor from products released by killed cells. Investigations into antagonistic bacterial interactions are important for our understanding of how the microbiota establish within hosts, influence health and disease, and offer insights into potential translational applications.
拮抗相互作用在微生物群落中很丰富，不仅有助于其成员的组成和相对比例，还有助于群落的长期稳定性。本综述主要关注由宿主相关微生物群落成员产生的核糖体合成肽和蛋白质介导的细菌拮抗作用。我们讨论了它们的多样性、功能和生态影响的最新发现。这些系统在生态系统防御、病原体入侵、空间隔离和多样性方面发挥着关键作用，但也通过被杀死的细胞释放的产物为攻击者带来间接收益。对抗性细菌相互作用的研究对于我们理解微生物群落在宿主内的建立方式、影响健康和疾病以及提供潜在转化应用的见解非常重要。
