Kim Hyun Jun, Lee Sang Yeoup, Kim Cheol Min
Department of Physical Education, Kyungnam University College of Education, Changwon, Republic of Korea.
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Biol Sport. 2018 Mar;35(1):21-27. doi: 10.5114/biolsport.2018.70748. Epub 2017 Oct 12.
Obesity is affected by genetic factors and environmental influences. This research was undertaken to identify single nucleotide polymorphisms (SNPs) related to obesity and physical fitness and then to analyse and compare interactions between physical fitness and obesity-associated genotypes. To investigate relationships between physical fitness and major SNPs previously reported to be related to obesity, 68 SNPs in 32 genes were genotyped in 71 Korean children. Tests were conducted to evaluate five elements of physical fitness (speed, aerobic endurance, muscular endurance, muscular strength, and flexibility). The results obtained showed significant (P<0.02) differences in physical fitness scores for the following genotypes: CNR1 (rs1049353; GG), LEP (rs7799039; AA+AG), HHEX (rs1111875; TT), GC (rs16847015; TG+GG), LRP5 (rs4988300; GG+GT), NPY2R (rs2880415; CT+CC), PPY (rs231472; GG), UCP2 (rs660339; CT+TT), CDKN2B (rs10811661; AA+AG), and ADIPOQ (rs266729; CG+GG). Ten physical fitness-related genotypes were newly identified during the present study. This study suggests that classification of genotypes by physical fitness level could be used as an index for predicting the risk of obesity and for selecting individuals for intervention programmes. Furthermore, the study shows that even children participating in the same physical fitness improvement programme can exhibit different genotype dependencies.
肥胖受遗传因素和环境影响。本研究旨在识别与肥胖和身体素质相关的单核苷酸多态性（SNP），然后分析和比较身体素质与肥胖相关基因型之间的相互作用。为了研究身体素质与先前报道的与肥胖相关的主要SNP之间的关系，对71名韩国儿童的32个基因中的68个SNP进行了基因分型。进行了测试以评估身体素质的五个要素（速度、有氧耐力、肌肉耐力、肌肉力量和柔韧性）。所得结果显示，以下基因型的身体素质得分存在显著（P<0.02）差异：CNR1（rs1049353；GG）、LEP（rs7799039；AA+AG）、HHEX（rs1111875；TT）、GC（rs16847015；TG+GG）、LRP5（rs4988300；GG+GT）、NPY2R（rs2880415；CT+CC）、PPY（rs231472；GG）、UCP2（rs660339；CT+TT）、CDKN2B（rs10811661；AA+AG）和ADIPOQ（rs266729；CG+GG）。在本研究中，新发现了10种与身体素质相关的基因型。本研究表明，按身体素质水平对基因型进行分类可作为预测肥胖风险和选择个体参加干预计划的指标。此外，研究表明，即使参与相同身体素质改善计划的儿童也可能表现出不同的基因型依赖性。
