Ramón Ricardo, Holguín Esteban, Chiriboga José Daniel, Rubio Newton, Ballesteros Carlos, Ezechieli Marco
St. Vincenz Hospital Location Salzkotten, 33154 Salzkotten, Germany.
QRA, 170184 Quito, Ecuador.
J Pers Med. 2023 Aug 25;13(9):1299. doi: 10.3390/jpm13091299.
Vitamin C, a potent reducing and antioxidant agent, plays an important role in the body, aiding in the growth of cartilage and bones. It is also involved in mechanisms that help reduce inflammation and its effects on the body. In addition, vitamin C decreases pro-inflammatory cytokines, such as IL-6, which produce acute-phase proteins such as CRP and influence inflammatory markers such as ESR. We carried out a study with 110 patients who underwent total knee replacement surgery. We divided the patients into two groups, in which the intervention group received 15 g of parenteral vitamin C during the immediate postoperative period while the control group did not. Patients who received 15 g of vitamin C after total knee replacement surgery had decreased inflammatory markers, specifically CRP and ESR. Overall, administering vitamin C in the post-surgical period results in improved management of inflammation, as evidenced by a decrease in CRP and ESR values. This leads to faster recovery and better healing outcomes for patients undergoing total knee replacement surgery. Furthermore, the beneficial effects of vitamin C in reducing proinflammatory cytokines, reducing the need for opioid analgesics, and its mild adverse effects make it a promising adjuvant in managing postoperative recovery.
维生素C是一种强效的还原剂和抗氧化剂，在人体中发挥着重要作用，有助于软骨和骨骼的生长。它还参与有助于减轻炎症及其对身体影响的机制。此外，维生素C可降低促炎细胞因子，如IL-6，IL-6可产生如CRP等急性期蛋白并影响如ESR等炎症标志物。我们对110例行全膝关节置换手术的患者进行了一项研究。我们将患者分为两组，干预组在术后即刻接受15克肠外维生素C，而对照组未接受。全膝关节置换手术后接受15克维生素C的患者炎症标志物，特别是CRP和ESR有所下降。总体而言，术后给予维生素C可改善炎症管理，CRP和ESR值降低证明了这一点。这使得接受全膝关节置换手术的患者恢复更快，愈合效果更好。此外，维生素C在减少促炎细胞因子、减少阿片类镇痛药需求方面的有益作用及其轻微的不良反应使其成为管理术后恢复的一种有前景的辅助药物。
