• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

负责多瘤病毒染色质中DNase I超敏反应的增强子序列。

Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.

作者信息

Bryan P N, Folk W R

出版信息

Mol Cell Biol. 1986 Jun;6(6):2249-52. doi: 10.1128/mcb.6.6.2249-2252.1986.

DOI:10.1128/mcb.6.6.2249-2252.1986
PMID:3023924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367766/
Abstract

DNase I preferentially cleaves polyomavirus minichromosomes at two sites in the enhancer, each of which comprises the sequence AAGCAPuPuAAG flanked by short inverted repeats. A tandem duplication of this sequence generates an additional hypersensitive locus. Mutations which alter either the AAGCAPuPuAAG or flanking repeats diminish hypersensitivity. This region must determine the chromatin conformation recognized by DNase I.

摘要

脱氧核糖核酸酶I优先在增强子的两个位点切割多瘤病毒微型染色体，每个位点都包含由短反向重复序列侧翼的AAGCAPuPuAAG序列。该序列的串联重复产生一个额外的超敏位点。改变AAGCAPuPuAAG或侧翼重复序列的突变会降低超敏性。该区域必定决定了脱氧核糖核酸酶I所识别的染色质构象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/26b07d4da78b/molcellb00090-0407-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/9668c5d49be7/molcellb00090-0406-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/957f49c8ba6b/molcellb00090-0406-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/ebf5a8315c55/molcellb00090-0407-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/26b07d4da78b/molcellb00090-0407-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/9668c5d49be7/molcellb00090-0406-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/957f49c8ba6b/molcellb00090-0406-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/ebf5a8315c55/molcellb00090-0407-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b4/367766/26b07d4da78b/molcellb00090-0407-b.jpg

相似文献

1
Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.负责多瘤病毒染色质中DNase I超敏反应的增强子序列。
Mol Cell Biol. 1986 Jun;6(6):2249-52. doi: 10.1128/mcb.6.6.2249-2252.1986.
2
Interaction of a nuclear factor with the polyomavirus enhancer region.
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8550-4. doi: 10.1073/pnas.83.22.8550.
3
Mapping of DNase I-hypersensitive sites in the 5' and 3' long terminal repeats of integrated moloney murine leukemia virus proviral DNA.整合的莫洛尼鼠白血病病毒前病毒DNA 5'和3'长末端重复序列中DNase I超敏位点的定位
Mol Cell Biol. 1985 Apr;5(4):601-9. doi: 10.1128/mcb.5.4.601-609.1985.
4
The polyomavirus enhancer activates chromatin accessibility on integration into the HPRT gene.多瘤病毒增强子在整合到次黄嘌呤磷酸核糖基转移酶基因时可激活染色质可及性。
Mol Cell Biol. 1992 Dec;12(12):5785-92. doi: 10.1128/mcb.12.12.5785-5792.1992.
5
Sites hypersensitive to, and protected from, nuclease digestion in the regulatory region of wild-type and mutant polyoma chromatin.野生型和突变型多瘤病毒染色质调控区域中对核酸酶消化敏感且受其保护的位点。
EMBO J. 1986 Dec 20;5(13):3539-46. doi: 10.1002/j.1460-2075.1986.tb04680.x.
6
Protein recognition sites in polyomavirus enhancer: formation of a novel site for NF-1 factor in an enhancer mutant and characterization of a site in the enhancer D domain.多瘤病毒增强子中的蛋白质识别位点：增强子突变体中NF-1因子新位点的形成及增强子D结构域中一个位点的特征分析
EMBO J. 1990 Mar;9(3):947-55. doi: 10.1002/j.1460-2075.1990.tb08193.x.
7
Unique requirement for the PyF441 mutation for polyomavirus infection of F9 embryonal carcinoma cells.F9胚胎癌细胞多瘤病毒感染对PyF441突变的独特要求。
J Virol. 1988 Aug;62(8):2896-902. doi: 10.1128/JVI.62.8.2896-2902.1988.
8
BK viral enhancer element and a human cellular homolog.BK病毒增强子元件和一种人类细胞同源物。
Science. 1983 Nov 18;222(4625):749-55. doi: 10.1126/science.6314501.
9
Multiple binding sites for polyomavirus large T antigen within regulatory sequences of polyomavirus DNA.多瘤病毒DNA调控序列内多瘤病毒大T抗原的多个结合位点。
J Virol. 1984 Dec;52(3):750-60. doi: 10.1128/JVI.52.3.750-760.1984.
10
Interaction of EF-C/RFX-1 with the inverted repeat of viral enhancer regions is required for transactivation.转录激活需要EF-C/RFX-1与病毒增强子区域的反向重复序列相互作用。
J Biol Chem. 1995 Apr 7;270(14):8353-60. doi: 10.1074/jbc.270.14.8353.

引用本文的文献

1
HSV as a gene transfer vector for the nervous system.单纯疱疹病毒作为神经系统的基因转移载体。
Mol Biotechnol. 1995 Aug;4(1):87-99. doi: 10.1007/BF02907473.
2
Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers.两种不同的因子与多瘤病毒增强子的α结构域结合，其中一种因子还与SV40和c-fos增强子相互作用。
EMBO J. 1987 May;6(5):1331-7. doi: 10.1002/j.1460-2075.1987.tb02372.x.
3
Nucleotides in the polyomavirus enhancer that control viral transcription and DNA replication.

本文引用的文献

1
Nucleosome structure.核小体结构。
Annu Rev Biochem. 1980;49:1115-56. doi: 10.1146/annurev.bi.49.070180.005343.
2
The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element.5型腺病毒E1A转录控制区包含一个重复的增强子元件。
Cell. 1983 Jul;33(3):695-703. doi: 10.1016/0092-8674(83)90012-0.
3
The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I.染色质中果蝇热休克基因的5'端对脱氧核糖核酸酶I高度敏感。
多瘤病毒增强子中控制病毒转录和DNA复制的核苷酸。
Mol Cell Biol. 1987 May;7(5):1681-90. doi: 10.1128/mcb.7.5.1681-1690.1987.
4
Molecular analysis of the interaction between an enhancer binding factor and its DNA target.增强子结合因子与其DNA靶点之间相互作用的分子分析。
Nucleic Acids Res. 1986 Dec 22;14(24):9595-611. doi: 10.1093/nar/14.24.9595.
5
Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.一种小鼠激活蛋白1（AP1）同源物和两种相邻蛋白对多瘤病毒增强子的激活作用。
Proc Natl Acad Sci U S A. 1988 Aug;85(16):5839-43. doi: 10.1073/pnas.85.16.5839.
6
DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro.多瘤病毒DNA在体内和体外复制的DNA序列要求。
Mol Cell Biol. 1987 Oct;7(10):3694-704. doi: 10.1128/mcb.7.10.3694-3704.1987.
Nature. 1980 Aug 28;286(5776):854-60. doi: 10.1038/286854a0.
4
A detailed mutational analysis of the eucaryotic tRNAmet1 gene promoter.真核生物甲硫氨酸tRNA1基因启动子的详细突变分析。
Cell. 1983 Jun;33(2):585-93. doi: 10.1016/0092-8674(83)90439-7.
5
Immunoglobulin gene transcription is activated by downstream sequence elements.免疫球蛋白基因转录由下游序列元件激活。
Cell. 1983 Jul;33(3):741-8. doi: 10.1016/0092-8674(83)90016-8.
6
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.一种淋巴细胞特异性细胞增强子位于免疫球蛋白重链基因连接区的下游。
Cell. 1983 Jul;33(3):729-40. doi: 10.1016/0092-8674(83)90015-6.
7
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.一种组织特异性转录增强子元件位于重排的免疫球蛋白重链基因的主要内含子中。
Cell. 1983 Jul;33(3):717-28. doi: 10.1016/0092-8674(83)90014-4.
8
Activation and function of chromatin.染色质的激活与功能
Horiz Biochem Biophys. 1983;7:43-70.
9
Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene.赋予鸡成年β-珠蛋白基因5'端核酸酶超敏感性的特定因子。
Proc Natl Acad Sci U S A. 1984 Jan;81(1):95-9. doi: 10.1073/pnas.81.1.95.
10
Specific interaction between enhancer-containing molecules and cellular components.含增强子分子与细胞成分之间的特异性相互作用。
Cell. 1984 Feb;36(2):403-11. doi: 10.1016/0092-8674(84)90233-2.