School of Medicine, Department of Orthopedics, University of Colorado, Boulder, CO.
College of Health Science, Carroll University, Waukesha, WI.
Med Sci Sports Exerc. 2019 Feb;51(2):271-277. doi: 10.1249/MSS.0000000000001790.
To assess the quality of the relationship between V˙O2peak estimated from patient outcomes on the 6-min walk test (6MWT) and the V˙O2peak calculated from patient outcomes on the University of Northern Colorado Cancer Rehabilitation Institute (UNCCRI) treadmill protocol.
Cancer survivors (N = 187) completed the UNCCRI treadmill protocol and a 6MWT 1 wk apart in randomized order to obtain V˙O2peak. Values from the UNCCRI treadmill protocol were compared against four common 6MWT V˙O2peak prediction equations.
All four 6MWT prediction equations significantly (P < 0.001) underestimated V˙O2peak with predicted values ranging from 8.0 ± 4.1 mL·kg·min to 18.6 ± 3.1 mL·kg·min, whereas the UNCCRI treadmill protocol yielded a significantly higher value of 23.9 ± 7.6 mL·kg·min. A positive strong correlation occurred between estimated V˙O2peak derived from the UNCCRI treadmill protocol and only one of the V˙O2peak values derived from the 6MWT prediction equations (r = 0.81), and all four equations consistently underpredicted V˙O2peak.
These findings suggest that the 6MWT is not a valid test for predicting V˙O2peak in the cancer population due to its consistent underestimation of V˙O2peak regardless of the prediction equation. Obtaining an accurate and valid V˙O2peak value is necessary to correctly prescribe an individualized exercise rehabilitation regimen for cancer survivors. It is recommended that clinicians avoid the 6MWT and instead implement treadmill testing to volitional fatigue to quantify V˙O2peak in cancer survivors.
评估从 6 分钟步行试验（6MWT）患者结果估计的 V˙O2peak 与从北科罗拉多大学癌症康复研究所（UNCCRI）跑步机方案患者结果计算的 V˙O2peak 之间的关系质量。
癌症幸存者（N=187）按随机顺序在 1 周内完成 UNCCRI 跑步机方案和 6MWT，以获得 V˙O2peak。将 UNCCRI 跑步机方案的值与四个常见的 6MWT V˙O2peak 预测方程进行比较。
所有四个 6MWT 预测方程均显著（P<0.001）低估了 V˙O2peak，预测值范围为 8.0±4.1 mL·kg·min 至 18.6±3.1 mL·kg·min，而 UNCCRI 跑步机方案则产生了一个显著较高的 23.9±7.6 mL·kg·min。UNCCRI 跑步机方案衍生的估计 V˙O2peak 与仅一个 6MWT 预测方程衍生的 V˙O2peak 值之间存在正强相关性（r=0.81），所有四个方程都一致低估了 V˙O2peak。
这些发现表明，6MWT 不是预测癌症患者 V˙O2peak 的有效测试，因为无论预测方程如何，它都持续低估 V˙O2peak。获得准确和有效的 V˙O2peak 值对于为癌症幸存者正确规定个性化运动康复方案是必要的。建议临床医生避免使用 6MWT，而是实施跑步机测试直至出现疲劳，以量化癌症幸存者的 V˙O2peak。
