Santek Nikolina, Langer Sanja, Kirac Iva, Velemir Vrdoljak Danko, Tometic Gordan, Musteric Goran, Mayer Ljiljana, Cigrovski Berkovic Maja
Department of Rheumatology, Physical Medicine and Rehabilitation, Sestre Milosrdnice UHC, 10000 Zagreb, Croatia.
Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia.
Cancers (Basel). 2025 May 26;17(11):1782. doi: 10.3390/cancers17111782.
Colorectal cancer is a significant health problem worldwide. Surgery is the primary curative treatment for most colorectal cancers. Cardiopulmonary exercise testing is now performed widely before surgery, and it is the most objective and precise means of evaluating pre-surgical physical fitness. Also, we can use the 6 min walk test to measure cardiorespiratory fitness before surgery. We included colorectal patients who were awaiting open abdominal or laparoscopic surgery. After admission to the hospital, patients who signed informed consent forms fulfilled a short questionnaire about health and physical status, preoperative physical activities, and quality of life questionnaire (EORTC QLQ-C30). Patients performed a 6 min walk test (6MWT) 2 days before surgery and 7 days after surgery. 6MWT is a tool for measuring the functional status of fitness. Also, they fulfilled the quality of recovery questionnaire (QoR 15) 7 days after surgery. In a final analysis, we included 72 patients with a mean age of 62.48. We compared the number of steps, walk distance, average and maximal walk speed, and average and maximal heart rate before and after surgery, overall, and by group. Our findings show a statistically significant difference between men and women in the walk distance ( = 4.99, = 0.02) The number of steps showed a statistically significant difference according to patients' ages ( = 2.90, = 0.02). Also, we detected differences in the average and maximum heart rate during walking when comparing body mass index (average heart rate = 5.72, = 0.00, maximum heart rate = 2.52, = 0.04). Our study provides evidence that average and maximal heart rate during the 6 min walk test was higher in the postoperative period, especially in overweight and obese participants.
结直肠癌是全球范围内一个重大的健康问题。手术是大多数结直肠癌的主要根治性治疗方法。目前,心肺运动试验在手术前被广泛应用,它是评估术前体能的最客观、精确的方法。此外,我们可以在手术前使用6分钟步行试验来测量心肺适能。我们纳入了等待开腹或腹腔镜手术的结直肠癌患者。入院后,签署知情同意书的患者填写了一份关于健康和身体状况、术前身体活动以及生活质量问卷(欧洲癌症研究与治疗组织QLQ-C30)的简短问卷。患者在手术前2天和手术后7天进行6分钟步行试验(6MWT)。6MWT是一种测量体能功能状态的工具。此外,他们在手术后7天填写了恢复质量问卷(QoR-15)。在最终分析中,我们纳入了72名平均年龄为62.48岁的患者。我们比较了手术前后总体以及按组别的步数、步行距离、平均和最大步行速度以及平均和最大心率。我们的研究结果显示,男性和女性在步行距离上存在统计学显著差异(F = 4.99,P = 0.02);步数根据患者年龄存在统计学显著差异(F = 2.90,P = 0.02)。此外,在比较体重指数时,我们发现步行期间的平均和最大心率存在差异(平均心率F = 5.72,P = 0.00,最大心率F = 2.52,P = 0.04)。我们的研究提供了证据,表明6分钟步行试验期间的平均和最大心率在术后更高,尤其是在超重和肥胖参与者中。