Department of Psychiatry, Yale School of Medicine, New Haven, CT.
Nicotine Tob Res. 2019 Sep 19;21(10):1423-1428. doi: 10.1093/ntr/nty187.
Cigarette smokers report using electronic cigarettes (e-cigarettes) to reduce or quit smoking, but findings are mixed regarding the benefit and risk of e-cigarettes in this population, and effects of gender are unknown.
The Population Assessment of Tobacco and Health (PATH; waves 1 and 2; adult interviews) was used to evaluate relationships among wave 1 e-cigarette use (daily, nondaily, never) and gender and their association with transitions (quit vs. current; relapse vs. former) in cigarette smoking status across waves 1 and 2 of the PATH study.
Daily e-cigarette users had higher odds of quitting smoking (odds ratio [OR] = 1.56, 95% confidence interval [CI] = 1.12 to 2.18) compared with never e-cigarette users. Conversely, daily and nondaily e-cigarette users were at greater risk of smoking relapse (OR = 1.84, 95% CI = 1.15 to 2.94 and OR = 1.85, 95% CI = 0.99 to 3.46, respectively) compared with never e-cigarette users. Women were less likely to quit smoking compared with men independent of e-cigarette use (OR = 0.76, 95% CI = 0.59 to 0.99). In stratified analyses, daily or nondaily e-cigarette use did not increase the likelihood of quitting or relapse in women. In men, daily and nondaily e-cigarette users were at greater risk of smoking relapse (OR = 2.96, 95% CI = 1.49 to 5.86 and OR = 3.05, 95% CI = 1.29 to 7.17, respectively) compared with men who were never e-cigarette users.
Findings identify e-cigarettes as a potential aid for smoking cessation but also as a potential risk for smoking relapse in men only. Overall, women were less likely to quit smoking, and e-cigarette use did not impact their ability to quit or to stay quit.
Cigarette smokers report using e-cigarettes to reduce or quit smoking, but findings are mixed regarding the benefit and risk of e-cigarettes in this population. Using data from the newly available PATH (waves 1 and 2; adult interviews), our findings identify e-cigarettes as a potential aid for smoking cessation but also identify e-cigarettes as a potential risk for smoking relapse in men only. These findings may have implications for the regulation of e-cigarettes by the Food and Drug Administration and the benefit-cost ratio of e-cigarette use in smokers.
吸烟人群报告使用电子烟（e-cigarettes）来减少或戒烟，但电子烟在该人群中的益处和风险的研究结果不一，且性别影响未知。
使用人口评估烟草和健康（PATH；第 1 波和第 2 波；成人访谈）评估第 1 波电子烟使用（每日、非每日、从不）与性别之间的关系，以及它们与第 1 波和第 2 波 PATH 研究中吸烟状况变化（戒烟与当前吸烟；复吸与曾经戒烟）之间的关联。
与从不使用电子烟的人群相比，每日使用电子烟的人群戒烟的可能性更高（优势比[OR] = 1.56，95%置信区间[CI] = 1.12 至 2.18）。相反，每日和非每日使用电子烟的人群复吸的风险更高（OR = 1.84，95% CI = 1.15 至 2.94 和 OR = 1.85，95% CI = 0.99 至 3.46）。与从不使用电子烟的人群相比，女性戒烟的可能性低于男性（OR = 0.76，95% CI = 0.59 至 0.99），独立于电子烟使用情况。
在分层分析中，每日或非每日使用电子烟并不能增加女性戒烟或复吸的可能性。对于男性，每日和非每日使用电子烟的人群复吸的风险更高（OR = 2.96，95% CI = 1.49 至 5.86 和 OR = 3.05，95% CI = 1.29 至 7.17），与从不使用电子烟的男性相比。
研究结果表明，电子烟可能是戒烟的一种潜在辅助手段，但也可能是男性复吸的潜在风险因素。总的来说，女性戒烟的可能性较低，电子烟的使用并未影响她们戒烟或保持戒烟的能力。
吸烟人群报告使用电子烟来减少或戒烟，但电子烟在该人群中的益处和风险的研究结果不一。使用新的 PATH 数据（第 1 波和第 2 波；成人访谈），我们的研究结果表明，电子烟可能是戒烟的一种潜在辅助手段，但也可能是男性复吸的潜在风险因素。这些发现可能对食品和药物管理局监管电子烟以及吸烟者使用电子烟的收益成本比产生影响。
