Silverstein F S, Chen R, Johnston M V
Neurosci Lett. 1986 Oct 30;71(1):13-8. doi: 10.1016/0304-3940(86)90249-1.
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/1 microliter) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain.
为评估谷氨酸激动剂quisqualic酸（QA）对未成熟脑的神经毒性，我们将该化合物（100纳摩尔QA/1微升）直接注射到7日龄大鼠的纹状体中。QA在14只幼鼠中引起神经元坏死和胶质细胞浸润，并减小了注射侧纹状体和海马体的大小。脑内注射QA为在发育中的大脑中产生神经元损伤提供了一种新方法。
