鸡的主要和次要卵黄蛋白原基因彼此相邻，且各自与对方部分缺失的假基因拷贝相邻。
The major and minor chicken vitellogenin genes are each adjacent to partially deleted pseudogene copies of the other.
作者信息
Silva R, Fischer A H, Burch J B
机构信息
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
出版信息
Mol Cell Biol. 1989 Aug;9(8):3557-62. doi: 10.1128/mcb.9.8.3557-3562.1989.
The major chicken vitellogenin gene (VTGII) has previously been cloned and sequenced. We now report the isolation of genomic clones that encompass a minor chicken vitellogenin gene (VTGIII) which is also expressed in the liver in response to estradiol. Our analysis reveals that a pseudogene for VTGII (psi VTGII) lies 1,426 base pairs upstream of this VTGIII gene. A reevaluation of published sequence data reveals that the converse is also true, namely, that a pseudogene for VTGIII (psi VTGIII) lies 1,345 base pairs downstream of the VTGII gene. Our results show that a 335-base-pair deletion has removed the psi VTGIII promoter and cap site but left residual estrogen response element in a region where nuclease-hypersensitive sites have been reported to be induced in response to estradiol.
主要的鸡卵黄生成素基因（VTGII）此前已被克隆和测序。我们现在报告分离出基因组克隆，其包含一个次要的鸡卵黄生成素基因（VTGIII），该基因在肝脏中也会因雌二醇而表达。我们的分析表明，VTGII的一个假基因（psi VTGII）位于该VTGIII基因上游1426个碱基对处。对已发表序列数据的重新评估表明，反之亦然，即VTGIII的一个假基因（psi VTGIII）位于VTGII基因下游1345个碱基对处。我们的结果表明，一个335个碱基对的缺失已去除psi VTGIII启动子和帽位点，但在据报道因雌二醇诱导产生核酸酶超敏位点的区域留下了残余的雌激素反应元件。
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