Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Sci Rep. 2018 Sep 21;8(1):14173. doi: 10.1038/s41598-018-32608-7.
With its capacity to modulate motor control and motivational as well as cognitive functions dopamine is implicated in numerous neuropsychiatric diseases. The present study investigated whether an imbalance in dopamine homeostasis as evident in the dopamine overexpressing rat model (DAT-tg), results in learning and memory deficits associated with changes in adult hippocampal neurogenesis. Adult DAT-tg and control rats were subjected to the Morris water maze, the radial arm maze and a discrimination reversal paradigm and newly generated neurons in hippocampal circuitry were investigated post mortem. DAT-tg rats were found to exhibit a striking inability to acquire information and deploy spatial search strategies. At the same time, reduced integration of adult-born neurons in hippocampal circuitry was observed, which together with changes in striatal dopamine signalling might explain behavioural deficits.
多巴胺具有调节运动控制和动机以及认知功能的能力，因此与许多神经精神疾病有关。本研究探讨了多巴胺稳态失衡是否会导致多巴胺过度表达大鼠模型（DAT-tg）出现学习和记忆缺陷，以及这种失衡是否与成年海马神经发生的变化有关。DAT-tg 大鼠和对照组大鼠接受了 Morris 水迷宫、放射臂迷宫和辨别逆转范式的测试，并且在死后研究了海马回路中新生成的神经元。研究发现，DAT-tg 大鼠明显无法获取信息和部署空间搜索策略。与此同时，观察到海马回路中成年新生神经元的整合减少，这与纹状体多巴胺信号的变化一起，可能解释了行为缺陷。
