Stokke T, Burchardi H, Hensel I, Köstering H, Käthner T, Rahlf G
Resuscitation. 1986 Sep;14(1-2):61-79. doi: 10.1016/0300-9572(86)90007-9.
In order to investigate the acute effects on lung morphology, lung function, hemodynamic and blood coagulation system, elastase (330 units (U) kg-1 h-1) was continuously infused into 16 anesthetized and mechanically ventilated minipigs. Elastase infusion induced a disturbance of blood coagulation leading to hypocoagulability, a pulmonary leukostasis, interstitial edema, a progressive respiratory failure with prompt increase in pulmonary vascular resistance, decrease in systemic vascular resistance, increased venous admixture, and increased dead space ventilation. Agranulocytosis prevented interstitial edema but not disturbances in pulmonary or hemodynamic function or hypocoagulability. The results clearly indicate that elastase may be involved in the pathophysiology of acute lung failure and defects in the blood coagulation system.
为了研究对肺形态、肺功能、血流动力学和血液凝固系统的急性影响，将弹性蛋白酶（330单位（U）/千克体重/小时）持续输注到16只麻醉并机械通气的小型猪体内。输注弹性蛋白酶引发了血液凝固紊乱，导致低凝状态、肺白细胞淤滞、间质水肿、进行性呼吸衰竭，伴有肺血管阻力迅速增加、体循环血管阻力降低、静脉血掺杂增加和死腔通气增加。粒细胞缺乏症可预防间质水肿，但不能预防肺或血流动力学功能紊乱或低凝状态。结果清楚地表明，弹性蛋白酶可能参与急性肺衰竭的病理生理学过程以及血液凝固系统的缺陷。
