Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas-SP 13083-970, Brazil.
Cell Metab. 2018 Oct 2;28(4):543-546. doi: 10.1016/j.cmet.2018.09.007. Epub 2018 Sep 20.
PAHSAs are anti-diabetic and anti-inflammatory lipids. Syed et al. identify numerous experimental differences that likely account for the failure of Pflimlin et al. to observe PAHSA beneficial effects. The differences include different HFDs resulting in minimal/no glucose intolerance, different assay conditions, an LC-MS protocol that was not validated, and use of olive oil, a bioactive nutrient that improves glucose tolerance, as a vehicle.
PAHSAs 是具有降血糖和抗炎作用的脂质。Syed 等人指出了许多可能导致 Pflimlin 等人未能观察到 PAHSA 有益效果的实验差异。这些差异包括使用不同的高脂肪饮食导致最小/无葡萄糖不耐受、不同的检测条件、未经验证的 LC-MS 方案以及使用橄榄油(一种可改善葡萄糖耐量的生物活性营养素)作为载体。