外膜囊泡保护病原体免受呼吸爆发产生的活性氧的侵害。
Outer Membrane Vesicles Protect the Pathogen From Reactive Oxygen Species of the Respiratory Burst.
作者信息
Lekmeechai Sujinna, Su Yu-Ching, Brant Marta, Alvarado-Kristensson Maria, Vallström Anna, Obi Ikenna, Arnqvist Anna, Riesbeck Kristian
机构信息
Clinical Microbiology and Molecular Pathology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
出版信息
Front Microbiol. 2018 Sep 7;9:1837. doi: 10.3389/fmicb.2018.01837. eCollection 2018.
Outer membrane vesicles (OMVs) play an important role in the persistence of infection. OMVs carry a plethora of virulence factors, including catalase (KatA), an antioxidant enzyme that counteracts the host respiratory burst. We found KatA to be enriched and surface-associated in OMVs compared to bacterial cells. This conferred OMV-dependent KatA activity resulting in neutralization of HO and NaClO, and rescue of surrounding bacteria from oxidative damage. The antioxidant activity of OMVs was abolished by deletion of KatA. In conclusion, enrichment of antioxidative KatA in OMVs is highly important for efficient immune evasion.
外膜囊泡（OMV）在感染的持续存在中发挥着重要作用。OMV携带大量毒力因子，包括过氧化氢酶（KatA），一种对抗宿主呼吸爆发的抗氧化酶。我们发现，与细菌细胞相比，KatA在OMV中富集并与表面相关。这赋予了OMV依赖的KatA活性，导致HO和NaClO的中和，并使周围细菌免受氧化损伤。KatA的缺失消除了OMV的抗氧化活性。总之，OMV中抗氧化性KatA的富集对于有效的免疫逃避非常重要。
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