Kerk Swat Kim, Lai Hui Ying, Sze Siu Kwan, Ng Kee Woei, Schmidtchen Artur, Adav Sunil S
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.
Front Microbiol. 2018 Sep 7;9:2145. doi: 10.3389/fmicb.2018.02145. eCollection 2018.
Apart from the skin surface, hair represents a significant tissue component with a capacity of bacterial interactions. New information can be obtained about hair function through the characterization of bacterial adherence, colonization, and responses to hair shafts In this proof-of-principle study, we examine the growth kinetics of Gram-positive and and Gram-negative and in the presence of human hair shafts. We explore the ability of these bacteria to adhere to and colonize hair shaft surfaces, as well as the resulting impact on the hair's surface morphology. We show that hair shafts inhibit the growth of Gram-positive and , while the growth kinetics of and remain unaffected. Scanning electron microscope analysis and steeping studies show that and to adhere to and colonize on human hair shafts without significantly affecting the hair shaft's surface morphology. produced a substantial amount of biofilm on the hair shaft surfaces, while specifically inhabited the edges of the cuticle scales. Taken together, our results demonstrate differences in bacterial responses to human hair shafts, which may provide novel insights into hair and scalp health.
除皮肤表面外，毛发是具有细菌相互作用能力的重要组织成分。通过对细菌黏附、定殖以及对毛干的反应进行表征，可以获得有关毛发功能的新信息。在这项原理验证研究中，我们研究了革兰氏阳性菌和革兰氏阴性菌在人毛干存在的情况下的生长动力学。我们探究了这些细菌黏附并定殖于毛干表面的能力，以及对毛发表面形态产生的影响。我们发现毛干会抑制革兰氏阳性菌和的生长，而和的生长动力学则不受影响。扫描电子显微镜分析和浸泡研究表明，和能够黏附并定殖于人毛干上，而不会显著影响毛干的表面形态。在毛干表面产生了大量生物膜，而则特别栖息在角质鳞片的边缘。综上所述，我们的结果证明了细菌对人毛干的反应存在差异，这可能为毛发和头皮健康提供新的见解。
