McDonnell J M, McDonnell P J, Mounts P, Wu T C, Green W R
Arch Ophthalmol. 1986 Dec;104(12):1801-5. doi: 10.1001/archopht.1986.01050240075043.
To investigate the association of human papillomavirus with conjunctival neoplasia, we identified 50 resected papillomas from 47 patients. Papillomas were composed of papillary or, less commonly, flat proliferations of predominantly nonkeratinizing squamous epithelium with admixed goblet cells. Koilocytosis was focally present in 30 tumors (60%). Atypia that ranged from mild to severe was present in ten lesions (20%). In addition, we examined specimens of conjunctival dysplasia or carcinoma from 61 patients. The lesions were predominantly flat proliferations of atypical epithelial cells. Twenty biopsies performed for suspected sarcoidosis were used as controls. Papillomavirus capsid antigen was demonstrated using an immunoperoxidase technique in nuclei of mature superficial epithelial cells of 23 papillomas (46%) and five dysplasias or carcinomas (8.2%) but not in the control biopsy specimens. These results suggest that papillomavirus may play a role in the etiology of conjunctival papilloma, dysplasia, and carcinoma.
为研究人乳头瘤病毒与结膜肿瘤的关联，我们从47例患者中识别出50个切除的乳头状瘤。乳头状瘤由乳头状或（较少见）扁平状增生构成，主要为非角化鳞状上皮，并伴有杯状细胞。30个肿瘤（60%）局部存在挖空细胞。10个病变（20%）存在从轻度到重度的异型性。此外，我们检查了61例患者的结膜发育异常或癌的标本。病变主要为非典型上皮细胞的扁平状增生。对20例疑似结节病进行的活检用作对照。采用免疫过氧化物酶技术在23个乳头状瘤（46%）以及5个发育异常或癌（8.2%）的成熟表层上皮细胞核中检测到乳头瘤病毒衣壳抗原，但在对照活检标本中未检测到。这些结果表明，乳头瘤病毒可能在结膜乳头状瘤、发育异常和癌的病因学中起作用。
