Ostrow R S, Manias D A, Fong W J, Zachow K R, Faras A J
Cancer. 1987 Feb 1;59(3):429-34. doi: 10.1002/1097-0142(19870201)59:3<429::aid-cncr2820590313>3.0.co;2-1.
We examined 217 tissue samples of various human malignancies for the presence of human papillomavirus (HPV) DNA using low-stringency filter hybridization techniques. These techniques were sufficiently sensitive for crosshybridization of the HPV DNA probes to all the known types of papillomavirus DNAs, both human and animal. Approximately 2% of the cancers analyzed contained HPV DNA. These included carcinomas of the lung, cecum, tongue, and neck. Three of four cancers contained HPV-16-related nucleotide sequences. Thus, in addition to previous data demonstrating the association of HPV DNA with certain cancers of the skin and genital tract, data is presented that indicates that several additional human cancers also contain HPV-related nucleotide sequences.
我们使用低严谨性滤膜杂交技术检测了217份各种人类恶性肿瘤的组织样本，以确定是否存在人乳头瘤病毒（HPV）DNA。这些技术对于HPV DNA探针与所有已知类型的人及动物乳头瘤病毒DNA进行交叉杂交而言灵敏度足够。所分析的癌症中约2%含有HPV DNA。这些包括肺癌、盲肠癌、舌癌和颈部癌。四份癌症中有三份含有与HPV - 16相关的核苷酸序列。因此，除了先前证明HPV DNA与某些皮肤和生殖道癌症相关的数据外，本文还提供了表明其他几种人类癌症也含有HPV相关核苷酸序列的数据。
