Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.
Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
J Dtsch Dermatol Ges. 2018 Oct;16(10):1197-1208. doi: 10.1111/ddg.13657. Epub 2018 Sep 24.
This study aimed to compare the efficacy of vitiligo treatments with and without ablation therapy.
We conducted a systematic review and meta-analysis of literature published before September 15, 2017. Comparative studies of vitiligo patients treated with and without ablation therapy were included. The primary outcome was ≥ 50 % repigmentation. Secondary outcomes were ≥ 75 % repigmentation and patient scores on a subjective visual analogue scale.
Fifteen studies with a total of 401 participants were included. The ablation-based combination therapy group had significantly superior results to the control group (odds ratio [OR] for ≥ 50 % repigmentation: 10.490, 95 % confidence interval [CI]: 4.632-23.757; OR for ≥ 75 % repigmentation: 5.812, 95 % CI: 2.194-15.393). Patients receiving ablation-based combination therapy were significantly more satisfied with the efficacy than the control group (standardized mean difference: 1.073, 95 % CI: 0.528-1.619). Subgroup analysis showed that the erbium laser group, CO laser group and fractional CO laser group achieved significantly better repigmentation than the control groups.
According to objective and subjective evaluations, treatments for vitiligo are more effective when combined with ablation therapy than when used alone.
本研究旨在比较有无消融治疗的白癜风治疗效果。
我们对截至 2017 年 9 月 15 日之前发表的文献进行了系统评价和荟萃分析。纳入了接受消融治疗与未接受消融治疗的白癜风患者的比较研究。主要结局是≥50%复色。次要结局是≥75%复色和患者主观视觉模拟评分。
纳入了 15 项研究，共计 401 名参与者。基于消融的联合治疗组的结果明显优于对照组（≥50%复色的比值比 [OR]：10.490，95%置信区间 [CI]：4.632-23.757；≥75%复色的 OR：5.812，95% CI：2.194-15.393）。接受基于消融的联合治疗的患者对疗效的满意度明显高于对照组（标准化均数差：1.073，95% CI：0.528-1.619）。亚组分析显示，铒激光组、CO 激光组和分数 CO 激光组的复色效果明显优于对照组。
根据客观和主观评估，与单独使用相比，消融治疗联合其他疗法治疗白癜风的效果更显著。
