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老年人认知功能与生活空间移动性的关系：来自 FRéLE 纵向研究的结果。

Association between cognitive function and life-space mobility in older adults: results from the FRéLE longitudinal study.

机构信息

Groupe de recherche Solidage, CSSS de la Montagne, site Metro, 1801, boulevard de Maisonneuve Ouest, bureau 600, Montréal, Québec, H3H 1J9, Canada.

École de santé publique, Département d'administration de la santé, Université de Montréal, C.P. 6128, succ. Centre-Ville, Montréal, Québec, H3C 3J7, Canada.

出版信息

BMC Geriatr. 2018 Sep 24;18(1):227. doi: 10.1186/s12877-018-0908-y.

DOI:10.1186/s12877-018-0908-y
PMID:30249199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6154880/
Abstract

BACKGROUND

Cross-sectional and longitudinal studies show conflicting results regarding the association between cognition and life-space mobility, and little is known regarding the mediators and moderators of the association. The aim of this study was to investigate the association between cognition and life-space mobility in older adults, as well as the intervening variables modifying the relationship.

METHODS

Community-dwelling older adults aged 65 years and older (N = 1643) were assessed at three time points over a period of 2 years. Growth mixture models with mediation and moderation analysis were utilised to investigate association between cognitive function and life-space mobility. The potential mediators and moderators were depressive symptoms, locus of control, gait speed and grip strength. Analysis was controlled for age, sex, education, annual income, number of chronic illnesses, and living site.

RESULTS

The direct association between initial scores of cognitive function and life-space was mediated by initial scores of depressive symptoms and gait speed, and moderated by initial scores of grip strength. No direct association between change in cognitive function and change in life-space mobility was found; the scores were mediated by change in depressive symptoms.

CONCLUSIONS

We conclude that the relationship between change in cognitive function and life-space mobility in older adults is not well-defined over an observation period of 2 years.

摘要

背景

横断面和纵向研究显示，认知功能与生活空间移动性之间的关联存在矛盾的结果，对于关联的中介和调节因素知之甚少。本研究旨在调查老年人认知功能与生活空间移动性之间的关联，以及改变这种关系的中介变量。

方法

对 1643 名年龄在 65 岁及以上的社区居住老年人进行了为期 2 年的 3 次评估。采用中介和调节分析的增长混合模型来研究认知功能与生活空间移动性之间的关联。潜在的中介和调节因素是抑郁症状、控制源、步态速度和握力。分析时控制了年龄、性别、教育程度、年收入、慢性疾病数量和居住地点。

结果

认知功能初始评分与生活空间之间的直接关联被初始抑郁症状评分和步态速度评分所中介，且被初始握力评分所调节。认知功能变化与生活空间移动性变化之间没有直接关联；评分由抑郁症状的变化所中介。

结论

我们得出结论，在 2 年的观察期内，老年人认知功能变化与生活空间移动性之间的关系不明确。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/5e749a9863b9/12877_2018_908_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/7adbc0bfa302/12877_2018_908_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/b62180802af1/12877_2018_908_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/f387aa7ffa6f/12877_2018_908_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/188509210d01/12877_2018_908_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/4e741646b12c/12877_2018_908_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/eec56e004bc7/12877_2018_908_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/5e749a9863b9/12877_2018_908_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/7adbc0bfa302/12877_2018_908_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/b62180802af1/12877_2018_908_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/f387aa7ffa6f/12877_2018_908_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/188509210d01/12877_2018_908_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/4e741646b12c/12877_2018_908_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/eec56e004bc7/12877_2018_908_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d85e/6154880/5e749a9863b9/12877_2018_908_Fig7_HTML.jpg

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