Smail Emily J, Rebok George W, Gross Alden L, Clay Olivio J, Ball Karlene, Crowe Michael, Kaufmann Christopher N, Manini Todd, Parisi Jeanine M
Department of Health Outcomes and Biomedical Informatics, University of Florida School of Medicine, Gainesville, FL, USA.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2025 May;32(3):411-426. doi: 10.1080/13825585.2024.2413720. Epub 2024 Oct 13.
We tested the longitudinal associations between life space mobility (LSM) at baseline and cognitive performance in three domains (memory, reasoning, and speed of processing) over time. Our analytic sample includes 2,690 older adults (mean age = 73.0, 75.9% female) participating in the ACTIVE Study. We used multiple linear mixed-effects models to evaluate whether LSM, measured using the Life Space Questionnaire, at baseline was longitudinally associated with scores on eight cognitive tests and three composite scores across 10 years. In unadjusted models, there were significant main effects of baseline LSM on memory and reasoning domains, and one speed of processing test (beta: 0.019 to 0.055, < 0.05). All effects were non-significant in adjusted models. Over time, baseline LSM was associated with one memory test score in adjusted models. Greater LSM at baseline is associated with marginally higher cognitive performance but does not appear to affect the rate of cognitive change at a clinically significant level.
我们测试了基线时的生活空间活动能力（LSM）与三个领域（记忆、推理和处理速度）随时间变化的认知表现之间的纵向关联。我们的分析样本包括2690名参与ACTIV研究的老年人（平均年龄 = 73.0岁，女性占75.9%）。我们使用多元线性混合效应模型来评估基线时使用生活空间问卷测量的LSM是否与10年内八项认知测试的分数和三项综合分数存在纵向关联。在未调整的模型中，基线LSM对记忆和推理领域以及一项处理速度测试有显著的主效应（β：0.019至0.055，P < 0.05）。在调整后的模型中，所有效应均不显著。随着时间的推移，在调整后的模型中，基线LSM与一项记忆测试分数相关。基线时较高的LSM与略高的认知表现相关，但似乎并未在临床上显著影响认知变化的速率。
