Baycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada
Baycrest Health Sciences, Rotman Research Institute, Toronto, Ontario M6A 2E1, Canada.
J Neurosci. 2018 Nov 7;38(45):9658-9667. doi: 10.1523/JNEUROSCI.0900-18.2018. Epub 2018 Sep 24.
The unique mapping of structural brain connectivity (SC) and functional brain connectivity (FC) on cognition is currently not well understood. It is not clear whether cognition is mapped via a global connectome pattern or instead is underpinned by several sets of distributed connectivity patterns. Moreover, we also do not know whether the spatial distributions of SC and FC that underlie cognition are overlapping or distinct. Here, we study the relationship between SC and FC and an array of psychological tasks in 609 subjects (males, 269; females, 340) from the Human Connectome Project. We identified several sets of connections that each uniquely map onto cognitive function. We found a small number of distributed SCs and a larger set of corticocortical and corticosubcortical FCs that express this association. Importantly, the SC and FC each show unique and distinct patterns of variance across subjects as they relate to cognition. The results suggest that a complete understanding of connectome underpinnings of cognition calls for a combination of the two modalities. Structural connectivity (SC), the physical white-matter inter-regional pathways in the brain, and functional connectivity (FC), the temporal coactivations between the activity of the brain regions, have each been studied extensively. Little is known, however, about the distribution of variance in connections as they relate to cognition. Here, in a large sample of subjects ( = 609), we showed that two sets of brain-behavior patterns capture the correlations between SC and FC with a wide range of cognitive tasks, respectively. These brain-behavior patterns reveal distinct sets of connections within the SC and the FC network and provide new evidence that SC and FC each provide unique information for cognition.
目前，人们对于结构连接（SC）和功能连接（FC）在认知方面的独特映射还了解甚少。尚不清楚认知是通过全局连接组模式来映射，还是由多组分布式连接模式来支撑。此外，我们也不知道认知所依赖的 SC 和 FC 的空间分布是否存在重叠或不同。在这里，我们在 609 名来自人类连接组计划的受试者（男性 269 名，女性 340 名）中研究了 SC 和 FC 与一系列心理任务之间的关系。我们确定了几组连接，它们各自与认知功能一一对应。我们发现了少量分布式的 SC，以及更多的皮质间和皮质下 FC 表达了这种关联。重要的是，SC 和 FC 在与认知相关的个体之间的变异性上都表现出独特而不同的模式。研究结果表明，要全面理解认知的连接组基础，需要将这两种模式结合起来。结构连接（SC）是大脑中物理的白质区域间通路，功能连接（FC）是大脑区域活动之间的时间协同作用，它们都已经被广泛研究。然而，关于连接的变异性与认知的关系，人们知之甚少。在这里，在一个大型受试者样本（n=609）中，我们表明，这两套脑行为模式分别捕捉了 SC 和 FC 与广泛认知任务之间的相关性。这些脑行为模式揭示了 SC 和 FC 网络内的不同连接组，并提供了新的证据，表明 SC 和 FC 各自为认知提供了独特的信息。
