Prince Mutaib bin Abdullah Chair for Biomarkers Research on Osteoporosis, Department of Biochemistry, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Saudi Arabia.
Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia.
Calcif Tissue Int. 2019 Feb;104(2):130-136. doi: 10.1007/s00223-018-0477-2. Epub 2018 Sep 24.
The present single-center observational study determined the prevalence and coexistence of sarcopenia, pre-sarcopenia, and metabolic syndrome (MetS) among apparently healthy Arab men and whether having both conditions present a unique cardiometabolic profile that is distinct than having the conditions separately.
A total of 471 out of 530 Arab men aged 20-77 years old were included after screening for the presence of pre-sarcopenia (ALM/ht < 7.26 kg/m), sarcopenia (presence of both low muscle mass and low function), and MetS. MetS screening was done using the definition by the NCEP-ATP III. Based on the screening results, the participants were classified as control (normal) group (N = 328), MetS only (N = 73), pre-sarcopenia only (N = 64), and MetS + pre-sarcopenia (N = 6).
Pre-sarcopenia without MetS was observed in 64 participants (13.6%), while MetS without pre-sarcopenia was observed in 73 participants (15.5%). MetS + pre-sarcopenia was observed only in 6 participants (1.3%). None of the participants had sarcopenia. Age- and BMI-adjusted comparisons showed that those with MetS + pre-sarcopenia had the highest diastolic blood pressure and triglyceride levels as compared to all groups (p values < 0.001). MetS + pre-sarcopenia group also had the highest levels of glucose and the lowest lean arms-legs/BMI ratio than control and pre-sarcopenia groups (p values < 0.001 and 0.005, respectively).
The prevalence of pre-sarcopenia + MetS is low among young adult Arab men, but shows a unique cardiometabolic profile that is worse than those having only one of the conditions. Further investigations should be done among Arab women and the elderly.
本单中心观察性研究旨在确定在看似健康的阿拉伯男性中，肌少症、肌少症前期和代谢综合征（MetS）的流行情况和共存情况，以及同时存在这两种情况是否会表现出一种独特的心血管代谢特征，与分别存在这两种情况有所不同。
在筛查出肌少症前期（ALM/ht<7.26kg/m）、肌少症（同时存在低肌肉量和低功能）和 MetS 后，共纳入了 530 名年龄在 20-77 岁的阿拉伯男性中的 471 名。MetS 筛查采用 NCEP-ATP III 定义。根据筛查结果，将参与者分为对照组（正常组，N=328）、MetS 组（N=73）、肌少症前期组（N=64）和 MetS+肌少症前期组（N=6）。
无 MetS 的肌少症前期患者有 64 名（13.6%），无肌少症前期的 MetS 患者有 73 名（15.5%）。仅发现 6 名（1.3%）患者同时患有 MetS 和肌少症前期。无患者患有肌少症。年龄和 BMI 调整后的比较显示，与所有组相比，同时患有 MetS 和肌少症前期的患者舒张压和甘油三酯水平最高（p 值均<0.001）。与对照组和肌少症前期组相比，MetS+肌少症前期组的血糖水平最高，瘦臂腿/BMI 比值最低（p 值均<0.001 和 0.005）。
在年轻的阿拉伯男性中，肌少症前期+MetS 的患病率较低，但表现出一种独特的心血管代谢特征，比仅有一种情况更差。应在阿拉伯女性和老年人中进一步开展调查。
