Yakout Sobhy M, Al-Daghri Nasser M, Bukhari Ihtisham, Khattak Malak N K, Sabico Shaun, Alokail Majed S, Al-Attas Omar S
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Translational Research Institute, Henan Provincial People's Hospital, Henan University, Zhengzhou, China.
Saudi J Biol Sci. 2020 Sep;27(9):2452-2456. doi: 10.1016/j.sjbs.2020.07.002. Epub 2020 Jul 9.
Low levels of vitamin D have been linked with increased adiposity and diminished muscle strength. Whether it is also related to fat deposition in muscle tissues is not studied well. This study explored the associations between circulating 25-hydroxyvitamin D (25(OH)D) and fat deposition in muscle tissues of adult Arab males. A total 465 adult Saudi males were included in this cross-sectional study. Anthropometrics, body composition and muscle strength were assessed. Serum 25(OH)D was determined and quantified enzymatically. They were grouped according to vitamin D status: deficient (25(OH)D < 50 nmol/l) N = 325 (69.9%) and sufficient (25(OH)D > 50 nmol/l)140 (30.1%). Mean level of lean/height, lean-arm-legs and lean-arms-legs/height were significantly higher in 25(OH)D deficient participants (p-values 0.03; 0.05 and 0.01 respectively). Thigh strength was significantly higher in 25(OH)D sufficient participants than their deficient counterparts (p = 0.02). In all participants, a significant correlation between 25(OH)D was observed with age and thigh-strength (p-values < 0.05), while a significant inverse correlation between 25(OH)D and lean/height, lean-arms-legs, lean-arms-legs/height, fat (%) region, fat arms, fat legs, fat trunk, lean legs were noted. In conclusion, low circulating 25(OH)D is associated with enhanced fat infiltration in muscle tissues of adult Arab males.
维生素D水平低与肥胖增加和肌肉力量减弱有关。它是否也与肌肉组织中的脂肪沉积有关尚未得到充分研究。本研究探讨了成年阿拉伯男性循环25-羟基维生素D（25(OH)D）与肌肉组织中脂肪沉积之间的关联。共有465名成年沙特男性纳入了这项横断面研究。评估了人体测量学、身体成分和肌肉力量。采用酶法测定并定量血清25(OH)D。根据维生素D状态将他们分组：缺乏组（25(OH)D＜50 nmol/l），N = 325（69.9%）；充足组（25(OH)D＞50 nmol/l），140（30.1%）。25(OH)D缺乏的参与者中，瘦体重/身高、瘦手臂和腿部、瘦手臂和腿部/身高的平均水平显著更高（p值分别为0.03、0.05和0.01）。25(OH)D充足的参与者的大腿力量显著高于缺乏组（p = 0.02）。在所有参与者中，观察到25(OH)D与年龄和大腿力量之间存在显著相关性（p值＜0.05），而25(OH)D与瘦体重/身高、瘦手臂和腿部、瘦手臂和腿部/身高、脂肪（%）区域、手臂脂肪、腿部脂肪、躯干脂肪、腿部瘦体重之间存在显著负相关。总之，低循环25(OH)D与成年阿拉伯男性肌肉组织中脂肪浸润增加有关。
