Adachi Mitsuru, Hozawa Soichiro, Nishikawa Masanori, Yoshida Atsushi, Jinnai Tatsunori, Tamura Gen
a International University of Health and Welfare/Sanno Hospital , Tokyo , Japan.
b Hiroshima Allergy and Respiratory Clinic, Hiroshima , Japan.
J Asthma. 2019 Sep;56(9):1016-1025. doi: 10.1080/02770903.2018.1514628. Epub 2018 Sep 25.
: The level of asthma control in adult asthma patients receiving treatment in clinical practice from allergy and/or respiratory specialists in Japan remains unclear. We conducted the ACQUIRE-2 study (NCT02640742) to evaluate level of asthma control, asthma symptoms, health-related quality of life (HR-QoL), and reliever medication use in this setting. : This observational study was undertaken between December 2015 and June 2016 in 58 medical institutions across Japan. We enrolled outpatients aged ≥20 years diagnosed with asthma for ≥1 year who were being managed by specialists. Criteria to evaluate the level of asthma control were based on modified definitions of the Asthma Prevention and Management Guideline 2015, Japan (JGL 2015) and Global Initiative for Asthma (GINA) 2012. Asthma symptoms, HR-QoL, and reliever medication use were also evaluated. : Of 1250 enrolled patients, 1175 were analyzed, 62.9% of whom were women. Mean (± standard deviation) age and duration of asthma were 59.7 ± 14.5 years and 16.9 ± 14.0 years, respectively. Using JGL 2015-based criteria, 24.4%, 69.2%, and 6.5% of patients had well-controlled, insufficiently-controlled, and poorly-controlled asthma, respectively. Using GINA-based criteria, 35.1%, 49.8%, and 15.1% of patients had controlled, partly controlled, and uncontrolled asthma, respectively. Daytime and nighttime asthma symptoms were experienced by 51.5% and 44.9% of patients, respectively. The mean MiniAQLQ score was 5.8 ± 1.0 (7-point scale). : Asthma was not well-controlled in the majority of patients in this study. To achieve better asthma control, improvements in symptom monitoring and management may be required.
在日本，接受过敏和/或呼吸专科医生临床治疗的成年哮喘患者的哮喘控制水平仍不明确。我们开展了ACQUIRE-2研究（NCT02640742），以评估这种情况下的哮喘控制水平、哮喘症状、健康相关生活质量（HR-QoL）和缓解药物使用情况。：这项观察性研究于2015年12月至2016年6月在日本全国58家医疗机构进行。我们纳入了年龄≥20岁、诊断为哮喘≥1年且由专科医生管理的门诊患者。评估哮喘控制水平的标准基于2015年日本哮喘预防和管理指南（JGL 2015）以及2012年全球哮喘防治创议（GINA）的修订定义。还对哮喘症状、HR-QoL和缓解药物使用情况进行了评估。：在1250名入组患者中，对1175名进行了分析，其中62.9%为女性。哮喘患者的平均（±标准差）年龄和病程分别为59.7±14.5岁和16.9±14.0年。根据基于JGL 2015的标准，分别有24.4%、69.2%和6.5%的患者哮喘得到良好控制、控制不充分和控制不佳。根据基于GINA的标准，分别有35.1%、49.8%和15.1%的患者哮喘得到控制、部分控制和未控制。分别有51.5%和44.9%的患者经历过白天和夜间哮喘症状。MiniAQLQ平均得分为5.8±1.0（7分制）。：本研究中的大多数患者哮喘控制不佳。为了实现更好的哮喘控制，可能需要改善症状监测和管理。
