Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and econstruction, Institute for Advanced Studgy and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
HKUST-Shenzhen Research Institute, No.9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China.
Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15189-15193. doi: 10.1002/anie.201810326. Epub 2018 Oct 22.
A particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher O generation efficiency than their small molecular counterparts. Furthermore, PSs with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures. Theoretical calculations suggest an enhanced intersystem crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.
具有给体-受体（D-A）结构的有机光敏剂（PS）的设计特别具有挑战性，因为它是基于反复试验而不是具体规则。现在，通过提出两种提高光致发光效率的有效策略来解决这些挑战：聚合促进的光致发光和 D-A 奇偶效应。已经发现共轭聚合物比它们的小分子对应物表现出更高的 O 生成效率。此外，具有 A-D-A 结构的 PS 比具有 D-A-D 结构的 PS 表现出更高的光致发光效率。理论计算表明，这些策略可以提高系间窜越（ISC）效率。体外和体内实验都表明，所得到的材料可用作图像引导光动力抗癌治疗中的光敏剂。这些准则适用于其他聚合物和小分子，以开发新的 PS。
