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香根草精油及其主要成分柠檬醛对离体大鼠主动脉收缩性的血管舒张作用。

Vasorelaxant effect of the Lippia alba essential oil and its major constituent, citral, on the contractility of isolated rat aorta.

机构信息

Postgraduate Programme in Molecular Bioprospection, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil.

Superior Institute of Biomedical Sciences, Ceará State University-UECE, 60740-903, Fortaleza, CE, Brazil.

出版信息

Biomed Pharmacother. 2018 Dec;108:792-798. doi: 10.1016/j.biopha.2018.09.073. Epub 2018 Sep 22.

Abstract

The Lippia alba (Mill.) N.E. Brown (Verbenaceae) species popularly known as lemon balm has sedative, analgesic and spasmolytic properties. This study aimed to evaluate the vasorelaxant effect of the L. alba essential oil (EOLa) and its major constituent, citral, rat on aorta. Isometric muscle contraction were induced by potassium (K 60 mM) or phenylephrine (PHE, 0.1 μM) in isolated aortic rings. EOLa and citral promoted a smooth muscle relaxant action, which was potentiated by the presence of the endothelium; PHE-induced contractions (0.1 μM) in aorta with endothelium, had EC values of 352.73 ± 19.39 μg/mL and 99.34 ± 7.2 μg/mL for EOLa and citral, respectively. In the presence of a nitric oxide synthase inhibitor, L-NAME, the EC values were 654.19 ± 10.46 μg/mL and 601.66 ± 10.922 μg/mL for EOLa and citral, respectively. EOLa and citral dose-dependently relaxed contractions induced by BAY-K 8644, a calcium channel agonist, and by Phorbol 12,13-dibutyrate an activator of protein kinase C. EOLa and citral produced a vasorelaxant effect in isolated aorta which was potentiated by the presence of endothelium. In summary, EOLa and citral, probably using several mechanisms of action, relaxed aortic smooth muscle with maximal pharmacologic efficacy.

摘要

莱菔硫烷(Mill.)N.E.布朗(马鞭草科)俗称柠檬香脂的物种具有镇静、镇痛和松弛平滑肌的特性。本研究旨在评估莱菔硫烷精油(EOLa)及其主要成分柠檬醛对大鼠主动脉的血管舒张作用。通过钾(K 60mM)或苯肾上腺素(PHE,0.1μM)诱导分离的主动脉环中的等长肌肉收缩。EOLa 和柠檬醛促进平滑肌松弛作用,内皮存在时增强;在有内皮的主动脉中,PHE(0.1μM)诱导的收缩,EOLa 和柠檬醛的 EC 值分别为 352.73±19.39μg/mL 和 99.34±7.2μg/mL。在一氧化氮合酶抑制剂 L-NAME 存在下,EOLa 和柠檬醛的 EC 值分别为 654.19±10.46μg/mL 和 601.66±10.922μg/mL。EOLa 和柠檬醛剂量依赖性地松弛 BAY-K 8644(钙通道激动剂)和佛波醇 12,13-二丁酸酯(蛋白激酶 C 激活剂)诱导的收缩。EOLa 和柠檬醛对分离的主动脉产生血管舒张作用,内皮存在时增强。总之,EOLa 和柠檬醛可能通过几种作用机制,以最大的药效松弛主动脉平滑肌。

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