Physiology Department, Minia University Faculty of Medicine, Minia University Faculty of Medicine, Minia, 61111, Egypt.
Human Anatomy Department, Minia University Faculty of Medicine, Minia University Faculty of Medicine, Minia, 61111, Egypt.
Biomed Pharmacother. 2018 Dec;108:799-808. doi: 10.1016/j.biopha.2018.09.093. Epub 2018 Sep 22.
Monosodium glutamate (MSG) is frequently consumed as a flavor enhancer or food additive. Possible MSG-induced injurious effects on some organs have been stated in experimental animal models. Thus, in this study we tried to clarify effect and possible mechanism of action of MSG on liver and kidney, and if this results affected by the addition of l-Arginine or vitamin D to it. Animals divided into; Control, MSG treated, MSG + vitamin D treated, MSG + L-arginine treated group. Serum separated to determine liver and kidney function parameters. Kidneys and livers dissected out for histological examination and for assay of oxidative stress markers. RESULTS: MSG increased body weight and produced liver and kidney dysfunctions. The MSG-induced oxidative liver and kidney damage was proved. Vitamin D and l- Arginine have been shown to protect and restore the liver and the kidney capabilities in MSG models injury via inhibiting oxidative damage, vitamin D or l- Arginine suppresses the increased food intake and body weight gain induced by MSG. CONCLUSIONS: due to injurious effect of MSG, it should be avoided especially in liver or kidney disorders, foods containing excess MSG can be fortified with vitamin D or l- Arginine to overcome its adverse effects.
味精（MSG）经常被用作增味剂或食品添加剂。在实验动物模型中已经指出，味精可能对某些器官造成伤害。因此，在这项研究中，我们试图阐明味精对肝脏和肾脏的作用和可能的作用机制，如果添加 l-精氨酸或维生素 D 会对此产生影响。动物分为：对照组、MSG 处理组、MSG+维生素 D 处理组、MSG+L-精氨酸处理组。分离血清以确定肝功能和肾功能参数。取出肾脏和肝脏进行组织学检查和氧化应激标志物检测。结果：MSG 增加了体重并导致肝功能和肾功能障碍。证实了 MSG 诱导的肝肾功能损伤。维生素 D 和 l-精氨酸已被证明可以通过抑制氧化损伤来保护和恢复 MSG 模型损伤中的肝脏和肾脏功能，维生素 D 或 l-精氨酸可以抑制 MSG 引起的食物摄入增加和体重增加。结论：由于 MSG 的有害作用，应避免在肝脏或肾脏疾病中使用，含有过量 MSG 的食物可以添加维生素 D 或 l-精氨酸来克服其不良反应。
