Wu Jiamin, Zhang Wenjie, Cai Junhong, Huang Sizhe, Niu Fanglin, Zhang Ying, Bao Shan, Jin Tianbo
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China.
Department of Women's Health Care, Northwest Women and Children Hospital, Xi'an, Shaanxi, China.
Mol Genet Genomic Med. 2019 May;7(5):e650. doi: 10.1002/mgg3.650. Epub 2019 Mar 20.
Recently, many studies have identified that genetic factor plays a crucial role in endometrial cancer development. The purpose of this study is to investigate the influence of single nucleotide polymorphisms (SNPs) of IL-1R2 on endometrial cancer susceptibility.
We performed a case-control study that included 293 patients with endometrial cancer and 579 healthy controls. Six SNPs in the IL-1R2 gene were genotyped using the Agena MassARRAY platform. Genetic models and haplotype analyses were used to assess the association between SNPs and endometrial cancer risk by computing odds ratios (ORs) and 95% confidence intervals (CIs).
Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk. Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup.
These findings suggested that IL-1R2 polymorphisms may contribute to the development of endometrial cancer. Further studies are required to confirm the results.
最近，许多研究已确定遗传因素在子宫内膜癌的发生发展中起关键作用。本研究的目的是探讨白细胞介素-1受体2（IL-1R2）单核苷酸多态性（SNP）对子宫内膜癌易感性的影响。
我们进行了一项病例对照研究，纳入293例子宫内膜癌患者和579例健康对照。使用Agena MassARRAY平台对IL-1R2基因中的6个SNP进行基因分型。通过计算比值比（OR）和95%置信区间（CI），采用遗传模型和单倍型分析来评估SNP与子宫内膜癌风险之间的关联。
总体分析结果发现，两个SNP（rs4851527和rs3218896）以及单倍型TGTC和TACT与子宫内膜癌风险显著相关。按年龄分层分析显示，rs2072472在年龄>54岁亚组中与子宫内膜癌风险相关。
这些发现表明，IL-1R2基因多态性可能与子宫内膜癌的发生有关。需要进一步研究来证实这些结果。
