Nelson Taylor A F, Blakey Simon B
Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, GA, 30322, USA.
Angew Chem Int Ed Engl. 2018 Nov 5;57(45):14911-14915. doi: 10.1002/anie.201809863. Epub 2018 Oct 15.
Herein we report on the development of an oxidative allylic C-H etherification reaction, utilizing internal olefins and alcohols as simple precursors. Key advances include the use of RhCp* complexes to promote the allylic C-H functionalization of internal olefins and the compatibility of the oxidative conditions with oxidatively sensitive alcohols, enabling the direct etherification reaction. Preliminary mechanistic studies, consistent with C-H functionalization as the rate determining step, are presented.
在此，我们报道了一种氧化烯丙基C-H醚化反应的开发，该反应利用内烯烃和醇作为简单的前体。关键进展包括使用RhCp*配合物促进内烯烃的烯丙基C-H官能化，以及氧化条件与对氧化敏感的醇的兼容性，从而实现直接醚化反应。本文还介绍了与C-H官能化作为速率决定步骤相一致的初步机理研究。
