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沙棘叶和枝的酚类部分和非极性部分：化学成分和生物活性。

Phenolic fraction and nonpolar fraction from sea buckthorn leaves and twigs: chemical profile and biological activity.

机构信息

Department of General Biochemistry, Faculty of Biology & Environmental Protection, University of Łódź, 90-236 Łódź, Poland.

Department of Biochemistry, Institute of Soil Science & Plant Cultivation, State Research Institute, 24-100 Puławy, Poland.

出版信息

Future Med Chem. 2018 Oct;10(20):2381-2394. doi: 10.4155/fmc-2018-0144. Epub 2018 Sep 27.

DOI:10.4155/fmc-2018-0144
PMID:30257568
Abstract

AIM

The main objective of our studies was to determine the chemical composition and biological activities (antioxidant and anticoagulant properties) of two standardized phenolic fractions from sea buckthorn twig and leaf, and two standardized nonpolar fractions from twig and leaf in human plasma in vitro.

MATERIAL & METHODS: Appropriately prepared extracts from sea buckthorn twigs and leaves were used. Markers of oxidative stress and hemostasis were determined in this work.

RESULTS

The reduction of plasma lipid peroxidation induced by HO/Fe was observed for two fractions from twig. Analysis of the effect on the coagulation properties of plasma demonstrated that the nonpolar fraction from twig and the phenolic fraction from leaf, significantly prolonged the activated partial thromboplastin time and the prothrombin time, respectively.

CONCLUSION

Sea buckthorn twig and leaf are new promising plant materials in the prophylaxis and treatment of cardiovascular disorders.

摘要

目的

我们研究的主要目的是确定沙棘嫩枝和叶的两种标准化酚类馏分以及嫩枝和叶的两种标准化非极性馏分在人血浆中的化学成分和生物活性（抗氧化和抗凝特性）。

材料与方法

使用了适当制备的沙棘嫩枝和叶提取物。本工作中测定了氧化应激和止血的标志物。

结果

观察到两种嫩枝馏分可减少 HO/Fe 诱导的血浆脂质过氧化。对血浆凝血特性的影响分析表明，嫩枝非极性馏分和叶酚类馏分分别显著延长了活化部分凝血活酶时间和凝血酶原时间。

结论

沙棘嫩枝和叶是预防和治疗心血管疾病的新的有前途的植物材料。

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