Kuroda Y, Shibasaki H, Sato H, Okochi K
Neurology. 1987 Jan;37(1):156-8. doi: 10.1212/wnl.37.1.156.
To examine the association between MS and anti-human T-cell lymphotropic virus-I (HTLV-I) antibody, we studied serum and CSF antibody to HTLV-I in 27 Japanese MS patients by an indirect immunofluorescence method sensitive and specific enough to detect carriers of HTLV-I. The antibody was detected in 3 of 27 MS patients (11.1%), in 4 of 48 patients (8.3%) with other neurologic diseases, and in 8.3% of 2,500 healthy blood donors. There was no significant difference in the incidence between the three groups. The titer of the antibody was low in CSF when compared with that in serum in all seropositive MS patients. Fluctuations in the CSF antibody titer were not observed in any of 14 MS patients sampled repeatedly.
为了研究多发性硬化症（MS）与抗人类嗜T细胞病毒I型（HTLV-I）抗体之间的关联，我们采用一种灵敏度和特异性足以检测HTLV-I携带者的间接免疫荧光法，对27例日本MS患者的血清和脑脊液（CSF）中的HTLV-I抗体进行了研究。在27例MS患者中有3例（11.1%）检测到该抗体，48例患有其他神经系统疾病的患者中有4例（8.3%）检测到该抗体，在2500名健康献血者中有8.3%检测到该抗体。三组之间的发病率没有显著差异。在所有血清阳性的MS患者中，CSF中抗体的滴度与血清中的相比很低。在14例重复采样的MS患者中，未观察到CSF抗体滴度的波动。
