Yu Angus P, Ugwu Felix N, Tam Bjorn T, Lee Paul H, Lai Christopher W, Wong Cesar S C, Siu Parco M
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Front Endocrinol (Lausanne). 2018 Sep 12;9:534. doi: 10.3389/fendo.2018.00534. eCollection 2018.
This study aimed to investigate how central obesity and hypertension modulate unacylated ghrelin (UnAG), acylated ghrelin (AG), obestatin, growth hormone (GH), and the ratios of UnAG/obestatin, AG/obestatin, and total ghrelin/obestatin. Circulatory abundances of UnAG, AG, obestatin and GH were determined in 387 Hong Kong Chinese female adults with age between 24 to 86 years based on a 2 × 2 factorial design of hypertension (blood pressure ≥140/90 mmHg) and central obesity (waist circumference or WC ≥80 cm). Participants were categorized as neither hypertensive nor centrally obese (NHNO; = 105), hypertensive but not centrally obese (HNO; = 102), centrally obese but not hypertensive (NHO; = 74) and hypertensive and centrally obese (NO; = 106). Pearson's correlation analyses were performed to detect the association between the peptides examined with WC and blood pressure. The main and interaction effects of hypertension and central obesity were examined by generalized estimating equations analyses. Correlation analyses revealed that systolic blood pressure was negatively correlated with AG/obestatin, UnAG/obestatin and total ghrelin/obestatin ratios, AG, total ghrelin, and GH, while diastolic blood pressure was negatively correlated with UnAG/obestatin, total ghrelin/obestatin ratios, and GH. WC was negatively correlated with AG/obestatin, UnAG/obestatin, and total ghrelin/obestatin ratios, UnAG, AG, total ghrelin, GH, and obestatin. Interaction effects of hypertension and central obesity were observed on UnAG/obestatin, AG/obestatin and total ghrelin/obestatin ratios, and obestatin. Obestatin in NHO group was significantly higher compared to NHNO and HO groups. UnAG/obestatin, AG/obestatin, and total ghrelin/obestatin ratios were higher in NHNO group compared to HNO and HO groups. Main effects of central obesity and hypertension were observed in UnAG, total ghrelin and GH. The HO group manifested the lowest level of UnAG, total ghrelin and GH among all the groups studied. Main effect of hypertension was observed on AG, suggesting that hypertensive individuals exhibited lower levels of AG regardless of central obesity. Circulatory ghrelin gene products and GH exhibit different modes of modulation in response to the co-manifestation of multiple cardiovascular risk factors compared with a single risk factor alone.
本研究旨在探讨中心性肥胖和高血压如何调节去酰基胃饥饿素（UnAG）、酰基化胃饥饿素（AG）、肥胖抑制素、生长激素（GH）以及UnAG/肥胖抑制素、AG/肥胖抑制素和总胃饥饿素/肥胖抑制素的比值。基于高血压（血压≥140/90 mmHg）和中心性肥胖（腰围或WC≥80 cm）的2×2析因设计，对387名年龄在24至86岁之间的中国香港成年女性进行了UnAG、AG、肥胖抑制素和GH的循环丰度测定。参与者被分为既无高血压也无中心性肥胖（NHNO；n = 105）、有高血压但无中心性肥胖（HNO；n = 102）、有中心性肥胖但无高血压（NHO；n = 74）以及有高血压且有中心性肥胖（NO；n = 106）。进行Pearson相关性分析以检测所检测的肽与WC和血压之间的关联。通过广义估计方程分析来检验高血压和中心性肥胖的主要效应及交互效应。相关性分析显示，收缩压与AG/肥胖抑制素、UnAG/肥胖抑制素和总胃饥饿素/肥胖抑制素比值、AG、总胃饥饿素和GH呈负相关，而舒张压与UnAG/肥胖抑制素、总胃饥饿素/肥胖抑制素比值和GH呈负相关。WC与AG/肥胖抑制素、UnAG/肥胖抑制素和总胃饥饿素/肥胖抑制素比值、UnAG、AG、总胃饥饿素、GH和肥胖抑制素呈负相关。在UnAG/肥胖抑制素、AG/肥胖抑制素和总胃饥饿素/肥胖抑制素比值以及肥胖抑制素方面观察到了高血压和中心性肥胖的交互效应。与NHNO组和HO组相比，NHO组的肥胖抑制素显著更高。与HNO组和HO组相比，NHNO组的UnAG/肥胖抑制素、AG/肥胖抑制素和总胃饥饿素/肥胖抑制素比值更高。在UnAG、总胃饥饿素和GH方面观察到了中心性肥胖和高血压的主要效应。在所有研究组中，HO组的UnAG水平、总胃饥饿素水平和GH水平最低。在AG方面观察到了高血压的主要效应，这表明无论是否存在中心性肥胖，高血压个体的AG水平都较低。与单一风险因素相比，循环胃饥饿素基因产物和GH在对多种心血管风险因素共同表现的反应中表现出不同的调节模式。
