Abdelmajed Samar Samir, Youssef Mohamed, Zaki Moushira Erfan, Abu-Mandil Hassan Naglaa, Ismail Somaia
October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Organic chemistry Department, Faculty of science, Cairo University, Egypt.
Genes Dis. 2017 Jul 4;4(3):170-175. doi: 10.1016/j.gendis.2017.06.002. eCollection 2017 Sep.
Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants.
肥胖是一种常见的疾病，对人类健康有重大影响，因为它可能导致许多严重疾病，有时甚至会引发死亡。先前的全基因组关联研究（GWAS）证实，脂肪量与肥胖相关基因（FTO）第一个内含子中的某些变异与不同种族成年人和儿童的肥胖之间存在关联。在我们的研究中，我们调查了埃及儿童和青少年中FTO基因rs9939609和rs17817449变异与肥胖的关联。我们检测了100例对照和100例肥胖病例中的rs9939609和rs17817449多态性，使用限制性片段长度多态性（RFLP）技术对样本进行基因分型。当前研究表明，rs17817449和rs9939609多态性的两个变异在病例组和对照组之间没有显著差异（P>0.05）。然而，rs17817449与胆固醇之间以及rs9939609与低密度脂蛋白之间存在显著相关性。在当前研究中，虽然这两个变异（rs9939609和rs17817449）与肥胖没有关联，但血脂谱与这两个变异之间存在相关性。
