He Zhen, Zhang Rong, Jiang Feng, Hou Wenjing, Hu Cheng
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Fengxian Central Hospital, Affiliated to Southern Medical University, 6600 Nanfeng Road, Shanghai, 201499, China.
Genes Dis. 2017 Nov 24;5(1):9-15. doi: 10.1016/j.gendis.2017.11.005. eCollection 2018 Mar.
A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.
最近的一些研究表明，DNA甲基化在脂质代谢调节中起着核心作用。DNA甲基化修饰是转录网络的重要调节因子，不影响DNA序列，可将遗传变异和环境因素转化为表型特征。因此，阐明个体间DNA甲基化变异的潜在因素，为我们提供了一个预测疾病并尽早干预异常DNA甲基化形成的机会。在这篇综述中，我们总结了DNA甲基化相关研究的结果，这些研究聚焦于揭示遗传和环境因素在DNA甲基化中的潜在作用，以及DNA甲基化对脂质代谢中基因表达的调节作用。
