CDV3在肝细胞癌预后评估中的潜在价值。
The potential value of CDV3 in the prognosis evaluation in Hepatocellular carcinoma.
作者信息
Xiao Heng, Zhou Baoyong, Jiang Ning, Cai Yunshi, Liu Xiongwei, Shi Zhengrong, Li Ming, Du Chengyou
机构信息
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China.
出版信息
Genes Dis. 2018 Jan 31;5(2):167-171. doi: 10.1016/j.gendis.2018.01.003. eCollection 2018 Jun.
CDV3 is correlated with tumorigenesis and may affect some biological process in cancer. In this study, we explore the role of CDV3 in HCC. According to the TCGA data base, CDV3 is over-expressed in HCC tissues. Up-regulation of CDV3 is correlated with lower over-all survival rate in HCC patients. In HCC samples from our hospital, CDV3 is also enriched in cancer tissues and CDV3 expression associated with HCC pathological T stage. What is more, higher CDV3 expression could forecast poor survival rate in HCC patients. In conclusion, CDV3 is a biomarker of HCC and could be a potential therapeutic target.
CDV3与肿瘤发生相关，可能影响癌症中的一些生物学过程。在本研究中，我们探讨了CDV3在肝癌中的作用。根据TCGA数据库，CDV3在肝癌组织中过度表达。CDV3的上调与肝癌患者较低的总生存率相关。在我们医院的肝癌样本中，CDV3在癌组织中也富集，且CDV3表达与肝癌病理T分期相关。此外，较高的CDV3表达可预测肝癌患者的低生存率。总之，CDV3是肝癌的一个生物标志物，可能是一个潜在的治疗靶点。
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