Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.
Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, China.
Adv Exp Med Biol. 2018;1087:275-285. doi: 10.1007/978-981-13-1426-1_22.
Metabolic diseases include diabetes mellitus (DM), obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Circular RNA is a new type of RNA that is different from traditional linear RNA and has a closed loop structure. However, the function of circular RNA is not yet well elucidated in metabolic diseases. Only a few studies have reported about the relationship between circular RNA and metabolic diseases such as DM and NAFLD. This chapter presents a brief review of epidemiology, pathophysiology, or treatment of DM and NAFLD and then discusses the relationship between circular RNA and DM or NAFLD. Besides, this chapter further provides an updated discussion of the most relevant discoveries regarding circular RNA and their potential applications in molecular diagnostics, nucleic acid therapy, and biomarkers.
代谢性疾病包括糖尿病（DM）、肥胖症、代谢综合征和非酒精性脂肪性肝病（NAFLD）。环状 RNA 是一种新型 RNA，不同于传统的线性 RNA，具有闭合环状结构。然而，环状 RNA 在代谢性疾病中的功能尚不清楚。只有少数研究报道了环状 RNA 与代谢性疾病（如 DM 和 NAFLD）之间的关系。本章简要综述了 DM 和 NAFLD 的流行病学、病理生理学或治疗方法，然后讨论了环状 RNA 与 DM 或 NAFLD 的关系。此外，本章还进一步讨论了环状 RNA 及其在分子诊断、核酸治疗和生物标志物方面的潜在应用的最新发现。
