Choi Ki-Choon, Cho Seong-Wan, Lee Jeong-Chae
2Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Cheonan, Chungnam, 31002 Korea.
3Department of Pharmaceutical Engineering, Konyang University, Nonsan, Chungnam, 32992 Korea.
Food Sci Biotechnol. 2016 Feb 29;25(1):349-353. doi: 10.1007/s10068-016-0049-z. eCollection 2016.
Red beans comprise part of the diet in Korean culture. Anti-inflammatory and anti-septic activities of the butanol fraction of red bean ethanol extracts (BF-RBEE) are known. The intestinal antiinflammatory activity of BF-RBEE and related mechanisms were studied using a rat model of acetic acid-induced colitis. Oral treatment with BF-RBEE (100 mg/kg of body weight) suppressed body weight loss and intestinal inflammatory damage in colitic rats. BF-RBEE treatment reduced the myeloperoxidase activity and the malondialdehyde level that were increased in colitic rats, and restored the reduced level of glutathione. BF-RBEE also inhibited acetic acid-mediated increases in mRNA levels of nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. Similarly, treatment with 1mg/kg of prednisolone protected rats against intestinal colitic damage with corresponding decreases in levels of these inflammatory indicators. Red beans can be useful for treatment of intestinal inflammatory diseases.
红豆是韩国文化饮食的一部分。已知红豆乙醇提取物的丁醇部分（BF-RBEE）具有抗炎和抗菌活性。使用醋酸诱导的大鼠结肠炎模型研究了BF-RBEE的肠道抗炎活性及其相关机制。用BF-RBEE（100mg/kg体重）口服治疗可抑制结肠炎大鼠的体重减轻和肠道炎症损伤。BF-RBEE治疗降低了结肠炎大鼠体内升高的髓过氧化物酶活性和丙二醛水平，并恢复了降低的谷胱甘肽水平。BF-RBEE还抑制了醋酸介导的一氧化氮合酶、白细胞介素-1β和肿瘤坏死因子-α mRNA水平的升高。同样，用1mg/kg泼尼松龙治疗可保护大鼠免受肠道结肠炎损伤，同时这些炎症指标的水平相应降低。红豆可用于治疗肠道炎症性疾病。
