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姜黄素通过诱导 HaCaT 细胞血红素加氧酶-1的表达来改善 TNF-α诱导的 ICAM-1 表达和随后的 THP-1 黏附。

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.

机构信息

Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chuncheon 200-702, Korea.

出版信息

BMB Rep. 2013 Aug;46(8):410-5. doi: 10.5483/bmbrep.2013.46.8.014.

DOI:10.5483/bmbrep.2013.46.8.014
PMID:23977989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4133911/
Abstract

Adhesion molecules such as ICAM-1 are important in the infiltration of leukocytes into the site of inflammation. In this study, we investigated the inhibitory effects of curcumin on ICAM-1 expression and monocyte adhesiveness as well as its underlying action mechanism in the TNF-α-stimulated keratinocytes. Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT. In addition, curcumin induced Nrf2 activation in dose- and time-dependent manners in the HaCaT cells. Curcumin suppressed TNF-α- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF-α-induced ICAM-1 expression and adhesion of monocytes to keratinocytes. These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-α-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes.

摘要

黏附分子如细胞间黏附分子-1（ICAM-1）在白细胞浸润炎症部位中起重要作用。在本研究中，我们研究了姜黄素对 TNF-α 刺激的角质形成细胞中 ICAM-1 表达和单核细胞黏附的抑制作用及其潜在作用机制。姜黄素诱导人角质形成细胞系 HaCaT 中血红素加氧酶-1（HO-1）的表达。此外，姜黄素以剂量和时间依赖的方式诱导 HaCaT 细胞中 Nrf2 的激活。姜黄素抑制 TNF-α诱导的 ICAM-1 表达和随后的单核细胞黏附，这可被 HO-1 的特异性抑制剂锡原卟啉 IX（SnPP）或使用 siRNA 敲低 HO-1 逆转。此外，使用 siRNA 敲低 Nrf2 可逆转姜黄素对 TNF-α诱导的 ICAM-1 表达和单核细胞与角质形成细胞黏附的抑制作用。这些结果表明，姜黄素可能通过在角质形成细胞中表达 HO-1 来抑制 TNF-α诱导的 ICAM-1 表达和随后的单核细胞黏附，从而发挥其抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/bc0bc63b4f29/BMB-46-410-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/82b25a5ee90d/BMB-46-410-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/3a9aa3be58da/BMB-46-410-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/52bacc5bd48c/BMB-46-410-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/bc0bc63b4f29/BMB-46-410-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/82b25a5ee90d/BMB-46-410-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/3a9aa3be58da/BMB-46-410-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/52bacc5bd48c/BMB-46-410-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/4133911/bc0bc63b4f29/BMB-46-410-g0004.jpg

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1
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BMB Rep. 2012 Jun;45(6):354-9. doi: 10.5483/bmbrep.2012.45.6.036.
2
Suppression of TNF-alpha-induced MMP-9 expression by a cell-permeable superoxide dismutase in keratinocytes.细胞通透型超氧化物歧化酶抑制角质形成细胞中 TNF-α诱导的 MMP-9 表达。
BMB Rep. 2011 Jul;44(7):462-7. doi: 10.5483/BMBRep.2011.44.7.462.
3
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Genes (Basel). 2022 Jan 25;13(2):223. doi: 10.3390/genes13020223.
4
DRM02, a novel phosphodiesterase-4 inhibitor with cutaneous anti-inflammatory activity.DRM02，一种具有皮肤抗炎活性的新型磷酸二酯酶-4 抑制剂。
Tissue Barriers. 2020 Jul 2;8(3):1765633. doi: 10.1080/21688370.2020.1765633. Epub 2020 Jun 1.
5
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Molecules. 2020 May 21;25(10):2396. doi: 10.3390/molecules25102396.
6
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Biochem Biophys Res Commun. 2011 Apr 15;407(3):535-40. doi: 10.1016/j.bbrc.2011.03.053. Epub 2011 Mar 23.
4
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Curr Drug Targets. 2011 Mar 1;12(3):332-47. doi: 10.2174/138945011794815356.
5
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Mol Nutr Food Res. 2011 Mar;55(3):430-42. doi: 10.1002/mnfr.201000221. Epub 2010 Oct 11.
6
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Biochem Pharmacol. 2010 Dec 15;80(12):1895-903. doi: 10.1016/j.bcp.2010.07.014. Epub 2010 Jul 17.
7
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Biochem Biophys Res Commun. 2010 Jul 16;398(1):140-5. doi: 10.1016/j.bbrc.2010.06.053. Epub 2010 Jun 17.
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