红参和黑参对老年小鼠大脑中胆碱能标志物、突触前标志物和神经营养因子的影响。
Effect of red and black ginseng on cholinergic markers, presynaptic markers, and neurotrophins in the brain of aged mice.
作者信息
Lee Mi Ra, Begum Shahnaz, Sung Chang Keun
机构信息
1Korea Institute of Oriental Medicine, Daegu, 41062 Korea.
2Department Food Science and Technology, Chungnam National University, Daejeon, 34134 Korea.
出版信息
Food Sci Biotechnol. 2017 Oct 16;26(6):1743-1747. doi: 10.1007/s10068-017-0235-7. eCollection 2017.
This study investigated the effects of chronic administration of red ginseng extract (RGE) and black ginseng extract (BGE) on memory impairment in aged (18-month-old) mice. RGE and BGE (200 mg/kg) were orally administered for 16 weeks. Aging induced DNA damage; however, RGE and BGE protected DNA from damage and allowed for DNA recovery in blood lymphocytes. Choline acetyltransferase, vesicular acetylcholine transporter, growth-associated protein 43, synaptosomal-associated protein 25, nerve growth factor, and brain-derived neurotrophic factor protein expression were significantly increased after treatment with RGE and BGE. These data suggest that chronic administration of red ginseng and black ginseng may decrease the cognitive deficits associated with normal aging.
本研究调查了长期给予红参提取物（RGE）和黑参提取物（BGE）对老年（18月龄）小鼠记忆损伤的影响。RGE和BGE（200毫克/千克）经口给药16周。衰老会导致DNA损伤；然而，RGE和BGE可保护DNA免受损伤，并使血液淋巴细胞中的DNA得以恢复。用RGE和BGE处理后，胆碱乙酰转移酶、囊泡乙酰胆碱转运体、生长相关蛋白43、突触体相关蛋白25、神经生长因子和脑源性神经营养因子的蛋白表达显著增加。这些数据表明，长期服用红参和黑参可能会减少与正常衰老相关的认知缺陷。
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