Hawkey C J, Holmes C H, Smith P G, Austin E B, Baldwin R W
Br J Cancer. 1986 Dec;54(6):871-5. doi: 10.1038/bjc.1986.255.
Reactivity of the monoclonal antibody 791T/36 with secondary malignant deposits has been investigated in frozen sections of 74 human liver biopsy specimens. There was no reactivity with hepatocytes but in some instances binding to fibrous tissues and in one case to portal tract lymphocytes was observed. Sections from 9 biopsy specimens contained malignant deposits. In seven of these 791T/36 bound either to malignant cells or to pseudoacinar contents (3 colorectal adenocarcinomas; 1 probable pancreatic adenocarcinoma; 1 medullary cell carcinoma of thyroid; 1 oat cell carcinoma of bronchus and 1 deposit of nodular sclerosing Hodgkins Disease). Two undifferentiated tumours (1 gastric adenocarcinoma and 1 oat cell bronchial carcinoma) showed no antibody binding. The histological pattern of reactivity previously reported with primary tumours appears to be similar in secondary deposits. A wider range of tumours than recognised hitherto binds 791T/36. Whether the binding to fibrous tissue seen in some instances is sufficient to cause diagnostic uncertainty when 791T/36 is used for scanning requires further investigation.
在74份人类肝脏活检标本的冰冻切片中，研究了单克隆抗体791T/36与继发性恶性沉积物的反应性。该抗体与肝细胞无反应，但在某些情况下可与纤维组织结合，在1例中观察到与门管区淋巴细胞结合。9份活检标本的切片中含有恶性沉积物。其中7份标本中，791T/36与恶性细胞或假腺泡内容物结合（3例结肠腺癌；1例可能的胰腺腺癌；1例甲状腺髓样癌；1例支气管燕麦细胞癌和1例结节硬化型霍奇金病沉积物）。2例未分化肿瘤（1例胃腺癌和1例支气管燕麦细胞癌）未显示抗体结合。先前报道的与原发性肿瘤相关的组织学反应模式在继发性沉积物中似乎相似。与迄今所认识的相比，更多类型的肿瘤可与791T/36结合。当791T/36用于扫描时，某些情况下与纤维组织的结合是否足以导致诊断不确定性，需要进一步研究。
