Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
World J Biol Psychiatry. 2019 Nov;20(9):723-731. doi: 10.1080/15622975.2018.1492735. Epub 2018 Sep 28.
Anorexia nervosa (AN) is a chronic illness where restriction of food intake results in decreased adipose tissue. The aim of this study was to measure the concentration of adiponectin and resistin in acute and partially weight-recovered anorectic inpatients. The associations of their levels with eating disorder symptoms were also assessed. A longitudinal study was conducted on 76 adolescent patients (ANG) and 30 age-matched healthy girls (CG). Selected adipokines serum levels, as well as the severity of depressive, obsessive-compulsive and disturbed eating behaviours, were analysed in the group of anorectic patients before (accAN) and after weight gain (recAN) and compared with the CG. The concentration of adiponectin in the accAN was higher than in the CG ( = 0.05) and increased in recAN ( = 0.01). Resistin concentrations were lower in accAN and recAN than in the CG ( 0.00). A negative correlation between adiponectin and the scores in Yale-Brown Obsessive Compulsive Scale as well as positive between resistin and Beck Depression Inventory were found. In the acute AN, adiponectin and resistin levels are impaired and partial weight recovery fails to normalise them thus we suggest that they can be involved in the chronicity of certain symptoms. The level of adiponectin is associated with obsessive and compulsive symptoms and resistin with depressive symptoms, which indicates their potential contribution to the regulation of emotions and behaviours in AN.
神经性厌食症（AN）是一种慢性疾病，其特征是限制食物摄入导致脂肪组织减少。本研究的目的是测量急性和部分体重恢复的神经性厌食症住院患者的脂联素和抵抗素浓度，并评估其水平与饮食失调症状的相关性。对 76 名青少年患者（ANG）和 30 名年龄匹配的健康女孩（CG）进行了纵向研究。在厌食症患者组中分析了选定的 adipokines 血清水平以及抑郁、强迫和饮食行为障碍的严重程度，在体重增加前（accAN）和增加后（recAN）与 CG 进行了比较。accAN 中的脂联素浓度高于 CG（ = 0.05），在 recAN 中增加（ = 0.01）。accAN 和 recAN 中的抵抗素浓度均低于 CG（ 0.00）。发现 adiponectin 与 Yale-Brown 强迫量表评分呈负相关，而 resistin 与 Beck 抑郁量表评分呈正相关。在急性 AN 中，脂联素和抵抗素水平受损，部分体重恢复未能使其正常化，因此我们认为它们可能参与了某些症状的慢性化。脂联素水平与强迫和强迫症状相关，抵抗素水平与抑郁症状相关，这表明它们可能对 AN 中的情绪和行为调节有贡献。
