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(12R)-和(12S)-羟基二十碳四烯酸对白细胞运动的激活作用以及[3H]白三烯B4从白细胞膜制剂中的移位

Activation of leukocyte movement and displacement of [3H]leukotriene B4 from leukocyte membrane preparations by (12R)- and (12S)-hydroxyeicosatetraenoic acid.

作者信息

Evans J F, Leblanc Y, Fitzsimmons B J, Charleson S, Nathaniel D, Léveillé C

出版信息

Biochim Biophys Acta. 1987 Feb 23;917(3):406-10. doi: 10.1016/0005-2760(87)90119-6.

DOI:10.1016/0005-2760(87)90119-6
PMID:3026490
Abstract

Both (12R)- and (12S)-hydroxyeicosatetraenoic acid were demonstrated to produce aggregation of rat leukocytes and enhance human leukocyte chemokinesis. (12R)-Hydroxyeicosatetraenoic acid was 10-20-fold more potent than (12S)-hydroxyeicosatetraenoic acid but at least 500-fold less potent than leukotriene B4 in these assays. These relative potencies are correlated with the potencies of (12R)- and (12S)-hydroxyeicosatetraenoic acid for competition of [3H]leukotriene B4 binding to rat and human leukocyte membrane preparations.

摘要

(12R)-羟基二十碳四烯酸和(12S)-羟基二十碳四烯酸均被证明可引起大鼠白细胞聚集并增强人白细胞趋化性。在这些试验中，(12R)-羟基二十碳四烯酸的效力比(12S)-羟基二十碳四烯酸强10 - 20倍，但比白三烯B4的效力至少低500倍。这些相对效力与(12R)-和(12S)-羟基二十碳四烯酸竞争[3H]白三烯B4与大鼠和人白细胞膜制剂结合的效力相关。

相似文献

1
Activation of leukocyte movement and displacement of [3H]leukotriene B4 from leukocyte membrane preparations by (12R)- and (12S)-hydroxyeicosatetraenoic acid.(12R)-和(12S)-羟基二十碳四烯酸对白细胞运动的激活作用以及[3H]白三烯B4从白细胞膜制剂中的移位
Biochim Biophys Acta. 1987 Feb 23;917(3):406-10. doi: 10.1016/0005-2760(87)90119-6.
2
Leukotriene B3, leukotriene B4 and leukotriene B5; binding to leukotriene B4 receptors on rat and human leukocyte membranes.白三烯B3、白三烯B4和白三烯B5；与大鼠和人白细胞膜上的白三烯B4受体结合。
Prostaglandins. 1986 Oct;32(4):503-16. doi: 10.1016/0090-6980(86)90033-x.
3
Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils.
J Leukoc Biol. 1995 Feb;57(2):257-63. doi: 10.1002/jlb.57.2.257.
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Studies on the mechanism of formation of the 5S, 12S-dihydroxy-6,8,10,14(E,Z,E,Z)-icosatetraenoic acid in leukocytes.白细胞中5S,12S - 二羟基 - 6,8,10,14（E,Z,E,Z）- 二十碳四烯酸形成机制的研究
Prostaglandins. 1982 May;23(5):713-24. doi: 10.1016/s0090-6980(82)80009-9.
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Stereospecificity of leukotriene B4 and structure-function relationships for chemotaxis of human neutrophils.白三烯B4的立体特异性与人中性粒细胞趋化性的结构-功能关系
J Immunol. 1984 Sep;133(3):1477-82.
6
Leukotriene B4 is an incomplete agonist for the activation of human neutrophils.白三烯B4是激活人类中性粒细胞的不完全激动剂。
Biochem Biophys Res Commun. 1984 Jul 31;122(2):535-41. doi: 10.1016/s0006-291x(84)80066-2.
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Analogs of leukotriene B4: effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors.白三烯B4类似物：羟基修饰对白细胞聚集及与白细胞白三烯B4受体结合的影响
Prostaglandins. 1987 May;33(5):617-25. doi: 10.1016/0090-6980(87)90029-3.
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Biological properties of dihydro-leukotriene B4, an alternative leukotriene B4 metabolite.二氢白三烯B4的生物学特性，一种替代性白三烯B4代谢产物。
FEBS Lett. 1988 Apr 25;231(2):385-8. doi: 10.1016/0014-5793(88)80855-x.
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Relationship of cyclic-AMP levels in leukotriene B4-stimulated leukocytes to lysosomal enzyme release and the generation of superoxide anions.
Biochim Biophys Acta. 1984 May 22;804(1):52-7. doi: 10.1016/0167-4889(84)90098-3.
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12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid is a more potent neutrophil chemoattractant than the 12(R) epimer in the rat cornea.在大鼠角膜中，12(S)-羟基-5,8,10,14-二十碳四烯酸比12(R)差向异构体是一种更强效的中性粒细胞趋化因子。
Prostaglandins. 1990 Aug;40(2):131-41. doi: 10.1016/0090-6980(90)90079-b.

引用本文的文献

1
Leukotriene receptors.白三烯受体
Clin Rev Allergy Immunol. 1999 Spring-Summer;17(1-2):179-91. doi: 10.1007/BF02737603.
2
Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice.
J Exp Med. 1997 Mar 17;185(6):1123-9. doi: 10.1084/jem.185.6.1123.
3
Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: impact upon leukotriene B4- and 12(R)-HETE-mediated events.第二代白三烯B4受体拮抗剂SC-53228的抗炎作用：对白三烯B4和12(R)-HETE介导事件的影响
Inflammation. 1995 Apr;19(2):193-205. doi: 10.1007/BF01534461.
4
Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid.12-羟基-5,8,10,14-二十碳四烯酸羟基对映体的体外淋巴细胞趋化活性对比
Br J Pharmacol. 1988 Nov;95(3):966-74. doi: 10.1111/j.1476-5381.1988.tb11727.x.
5
A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.一种具有新型立体选择性的区域特异性单加氧酶是分离的表皮细胞中花生四烯酸氧化的主要途径。
J Clin Invest. 1989 Nov;84(5):1446-53. doi: 10.1172/JCI114319.