12-羟基-5,8,10,14-二十碳四烯酸羟基对映体的体外淋巴细胞趋化活性对比
Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid.
作者信息
Bacon K B, Camp R D, Cunningham F M, Woollard P M
机构信息
Institute of Dermatology, St. Thomas's Hospital, London.
出版信息
Br J Pharmacol. 1988 Nov;95(3):966-74. doi: 10.1111/j.1476-5381.1988.tb11727.x.
Abstract
- The chemotactic activity of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE), 12(S)-HETE and leukotriene B4 (LTB4) for human mixed peripheral blood lymphocytes has been assessed in a 48-well microchemotaxis assay. Responses to the standard lymphocyte chemoattractants, zymosan-activated plasma, casein and N-formyl-methionyl-leucyl-phenylalanine (fMLP) were also measured. 2. 12(R)-HETE was shown to be chemotactic for lymphocytes over the range 5 x 10(-7) to 5 x 10(-5) M. In contrast, negligible chemotactic responses to 12(S)-HETE were obtained. 3. LTB4 was 200 times more potent than 12(R)-HETE as a lymphocyte chemoattractant, although maximal responses to the two agonists were similar. 4. 12(R)-HETE and LTB4, which are present in extracts of samples from the skin lesions of psoriasis, may be, at least in part, responsible for the lymphocyte infiltrate which is a characteristic feature of this disease.
摘要
- 在48孔微量趋化性分析中评估了12(R)-羟基-5,8,10,14-二十碳四烯酸（12(R)-HETE）、12(S)-HETE和白三烯B4（LTB4）对人外周血混合淋巴细胞的趋化活性。还测定了对标准淋巴细胞趋化剂酵母聚糖激活血浆、酪蛋白和N-甲酰甲硫氨酰亮氨酰苯丙氨酸（fMLP）的反应。2. 结果显示12(R)-HETE在5×10⁻⁷至5×10⁻⁵M范围内对淋巴细胞具有趋化作用。相比之下，对12(S)-HETE的趋化反应可忽略不计。3. 作为淋巴细胞趋化剂，LTB4的效力比12(R)-HETE高200倍，尽管对这两种激动剂的最大反应相似。4. 银屑病皮肤病变样本提取物中存在的12(R)-HETE和LTB4可能至少部分导致了淋巴细胞浸润，这是该疾病的一个特征。
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