Blednov Iu A, Gordeĭ M L, Seredenin S B
Biull Eksp Biol Med. 1987 Jan;103(1):61-3.
The influence of sodium chloride and gamma-aminobutyric acid (GABA) on H3-diazepam binding in CNS membrane fraction were investigated in C57Bl/6, BALB/c mice and their F1 hybrids. The addition of GABA (1, 10 and 100 microM) elevated the level of radioligand binding with CNS membranes in all the inbred mice in similar manner. The higher stimulating effect of sodium chloride (50, 100 and 150 mM) on the H3-diazepam reception was found in BALB/c mice and F1 hybrids, as compared to C57Bl/6 mice. It has been suggested that membrane-dependent conformational reconstructions of supramolecular receptor complex are the cause of genetic differences in the regulation of H3-diazepam reception by Cl(-)-ionophore.
在C57Bl/6、BALB/c小鼠及其F1杂种小鼠中，研究了氯化钠和γ-氨基丁酸（GABA）对中枢神经系统膜组分中H3-地西泮结合的影响。添加GABA（1、10和100微摩尔）以相似的方式提高了所有近交系小鼠中枢神经系统膜的放射性配体结合水平。与C57Bl/6小鼠相比，在BALB/c小鼠和F1杂种小鼠中发现氯化钠（50、100和150毫摩尔）对H3-地西泮受体具有更高的刺激作用。有人提出，超分子受体复合物的膜依赖性构象重建是Cl(-)离子载体调节H3-地西泮受体的遗传差异的原因。
