Stevens J R, Phillips I, de Beaurepaire R
Neuropsychiatry Branch, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032.
Epilepsia. 1988 Jul-Aug;29(4):404-11. doi: 10.1111/j.1528-1157.1988.tb03739.x.
Suppression of kindled amygdala seizures in rats followed bilateral infusion of the GABA transaminase inhibitor gamma-vinyl-GABA (GVG) into the endopiriform area of the forebrain. The deep prepiriform cortex of the rat is an important site for both initiation and arrest of generalized seizures induced by systemic convulsants. To determine whether this area also regulates the spread of amygdala seizures, the irreversible GABA-transaminase blocking agent, GVG (vigabatrin) was infused bilaterally in the deep prepiriform area in amygdala-kindled rats. Twenty-four hours after the infusion, kindled seizure threshold was elevated in 12 of 13 rats tested. If homologous areas exist in the primate brain, treatment strategies that take advantage of critical areas for seizure spread by local infusion of inhibitory agents or transplantation of GABA-containing cells may be developed for suppressing intractable seizures in humans.
在大鼠前脑内梨状区双侧注入γ-乙烯基-GABA（GVG）这种γ-氨基丁酸转氨酶抑制剂后，点燃杏仁核癫痫发作受到抑制。大鼠的深层梨状前皮质是全身性惊厥剂诱发的全身性癫痫发作起始和终止的重要部位。为了确定该区域是否也调节杏仁核癫痫发作的扩散，将不可逆的γ-氨基丁酸转氨酶阻断剂GVG（氨己烯酸）双侧注入杏仁核点燃大鼠的深层梨状前皮质。注入24小时后，在接受测试的13只大鼠中，有12只的点燃癫痫发作阈值升高。如果灵长类动物大脑中存在同源区域，那么利用通过局部注入抑制剂或移植含γ-氨基丁酸的细胞来利用癫痫发作扩散关键区域的治疗策略，可能会被开发用于抑制人类的顽固性癫痫发作。
